LRRC3B在非小细胞肺癌中表达下调及其与高TNM分期、淋巴结转移的相关性

摘要

目的：探讨LRRC3B在非小细胞肺癌（non-small cell lung cancer，NSCLC）中的表达情况及其与临床病理参数的关系。方法选取2008～2011年于本院就诊的101例NSCLC患者的组织标本及20例癌旁正常组织标本纳入本研究。采用免疫组织化学法检测入选标本中LRRC3B的表达情况，分析其与NSCLC患者各临床病理参数的关系。结果 LRRC3B阳性信号定位于细胞质。LRRC3B在正常支气管上皮细胞及肺泡细胞中均为阳性表达。在肺癌组织中，LRRC3B高表达62例（61.4%），低表达39例（38.6%），且LRRC3B的表达特点在不同TNM分期以及不同淋巴结转移情况的组织间存在显著差异（P＜0.05）。结论 LRRC3B在NSCLC中表达下调，并与肿瘤高TNM分期以及淋巴结转移显著相关。%ObjectiveTo investigate the expression of LRRC3B in non-small cell lung cancer (NSCLC) and its correlation with clinicopathological parameters of NSCLC.MethodThe expression of LRRC3B in 101 NSCLC samples and 20 normalsamples which were collected from 2008 to 2001 in our hospital were detected through immunohistochemical technology, and the relationship between the expression of LRRC3B and clinicopathological parameters were also performed.ResultLRRC3B was dominantly located in the cytoplasm. LRRC3B was positive staining in bronchial epithelial cells and alveolar cells of normal lung tissues. Among the NSCLC samples, 61.4% (62/101) were high expression and 38.6% (39/101) were low expression. The expression of LRRC3B was correlated with TNM stage and lymph node metastasis. ConclusionLRRC3B is downregulated in NSCLC and correlated with advanced TNM stage and lymph node metastasis.