Ang-2、HSP90α在老年非小细胞肺癌患者血清中的表达及与TNM分期的相关性研究

摘要

Objective The expression of Ang-2 and HSP90α in serum of patients with non-small cell lung cancer and their correlation with TNM staging were analyzed.Methods From January 2015 to June 2016,40 patients with elderly non-small cell lung cancer and 40 healthy persons were selected as the study subjects.The serum levels of Ang-2 and HSP90 alpha in the subjects were examined and their correlation with the TNM stage of the patients was analyzed.Results Observation of Ang-2 and HSP90α levels in the serum of the patients group were significantly higher than the control group,and the difference was statistical significance(P<0.05);Serum Ang-2 and HSP90α levels TNM Ⅰ-Ⅱ patients were significantly lower than that of stage Ⅲ and Ⅳ,the difference was statistical significance(P<0.05);Serum Ang-2 and HSP90α levels in TNM Ⅲ patients was significantly lower than those in stage Ⅲ and Ⅳ,the difference was statistical significance(P<0.05);TNM staging was positively correlated with the levels of HSP90α in serum,and statistical significance(r=0.425,P<0.05),TNM stage had a remarkably positive correlation with the level of Ang in serum(r=0.525,P<0.05).Conclusion The levels of Ang-2 and HSP90α were significantly higher in the serum of elderly patients with non-small cell lung cancer,and the expression level was positively correlated with TNM stage.%目的 分析血管生成素-2(Ang-2)、热休克蛋白-90α(HSP90α)与老年非小细胞肺癌患者血清中表达情况,及其与TNM分期的相关性.方法 选取2015年1月至2016年6月间新疆医科大学附属中医医院收治的40例老年非小细胞肺癌患者及40例体检健康者作为研究对象.检测受试者血清中Ang-2、HSP90α水平,并分析其与患者TNM分期相关性.结果 观察组患者血清中Ang-2及HSP90α水平均明显高于对照组,差异有统计学意义(P<0.05);肿瘤TNM Ⅰ～Ⅱ期患者血清中Ang-2及HSP90α水平显著低于Ⅲ及Ⅳ期,差异有统计学意义(P<0.05);TNM Ⅲ期患者血清中Ang-2及HSP90α水平显著低于Ⅳ期,差异存统计学意义(P<0.05);TNM分期与患者血清中HSP90α水平呈正相关(r=0.425,P<0.05),TNM分期与患者血清中Ang水平呈正相关(r=0.525,P<0.05).结论 Ang-2及HSP90α水平在老年非小细胞肺癌患者血清中呈显著高表达状态,且其表达水平与TNM分期呈正相关.