目的:探讨在体外受精-胚胎移植(IVF - ET)周期控制性超排卵(COH)中出现临床卵巢低反应患者的临床特征及其再治疗策略.方法:回顾性分析接受IVF - ET治疗,表现为临床卵巢低反应的189例患者临床资料(以获卵≤4枚为诊断标准),并按照患者年龄分为≤30岁、＞ 30～ 35岁、＞35岁3组；未妊娠接受第2次IVF - ET治疗共71个周期的临床资料进行自身对照分析.结果:第1周期治疗中,≤30岁组、＞ 30～35岁组优质胚胎率和妊娠率均高于＞35岁组,周期取消率低于＞35岁组；第2周期调整COH方案可以获得正常的卵巢反应；对于卵巢低反应的高龄 患者,小剂量的生长激素可以增加其优质胚胎率.结论:在COH方案中,部分卵巢低反应患者存在卵巢反应的不一致性,应结合既往超排经历重新评估卵巢储备.%Objective: To explore clinical characteristics of women with poor ovarian response in controlled ovarian hyperstimu-lation ( COH) during in vitro fertilization and embryo transfer (IVF - ET) and the outcome of retreatment. Methods: A retrospective study was conducted on 189 women who had ever had poor response in the first cycle of IVF - ET. Women were divided into three groups according to their ages: group A ( less than 30 years old) , B (30 to 35 years old) , and C ( more than 35 years old). A total of 71 women who failed to get pregnant received treatment again. Results; In the first treatment cycle, more high - quality embryos and higher clinical pregnancy rate were found in group A and B, and the cycle cancellation rates were lower in group A and B. Normal ovarian response to COH was found in women who had ever had poor response after changing the protocol. Low dose of growth hormone could increase the number of high - quality embryo. Conclusion: An inconsistent response could be found in some women with poor ovarian response in COH. And their ovarian reserve should be reassessed on the basis of the history of COH.
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