Objective:To investigate the effect of low dose of propylthiouracil on the outcomes of pregnancy and liver function of pregnant women with hyperthyroidis.Methods:296 pregnant women with hyperthyroidism from the Fourth Affiliated Hospital of Nanchang University were recruited between April 2015 and November 2016.The included pregnant women with hyperthyroidism were divided into the control group and the research group according to the random number table,and each group had 148 women.The women in the control group were treated with routine dose of propylthiouracil,women in the study group were treated with low dose propylthiouracil.The serum thyroid function related indexes (FT3,FT4 and TSH) and liver function related indexes (ALT,AST,ALP,GGT and TBIL) of all women were detected before and after treatment.The efficacy of treating hyperthyroidism of women was evaluated,and the adverse events of women were analyzed.Results:Before treatment,the levels of serum FT3,FT4 and TSH of women in the two groups were no significant difference (P＞0.05),and after treatment,the levels of serum FT3 and FT4 of women in the two groups were significantly lower than those of women before treatment (P＜0.05),while the level of TSH of women after treatment was significantly higher than that of women before treatment (P＜0.05),but there was no statistical significant difference in levels of FT3,FT4 and TSH between the two groups (P＞0.05).The total efficiency of treating hyperthyroidism had no significant difference between the two groups (P＞0.05).The levels of serum ALP,GGT and TBIL of women in the two groups before treatment had no statistical significant difference when compared to those of women after treatment (P＞0.05).After treatment,the levels of ALT and AST of women in the control group had increased,and were significant higher than those of women in the study group (P＜0.05).The total incidence of adverse events of women in the study group (12.84％) was significant lower than that of women in the control group (22.97 ％) (x2 =3.96,P =0.000,＜0.05).Conclusion:Compared with the conventional dose of propylthiouracil,low dose of propylthiouracil using in pregnant women with hyperthyroidism not only can achieve the treating efficacy of hyperthyroidism,but also can significantly reduce the degree of damage of liver function,decrease adverse reactions during pregnancy,and can improve the pregnancy outcomes.%目的:观察低剂量丙硫氧嘧啶对妊娠合并甲亢患者妊娠结局和肝功能的影响.方法:2015年4月-2016年11月本院接受治疗的296例妊娠合并甲亢患者为研究对象,按照随机数字表法分为观察组和对照组各148例,对照组常规剂量丙硫氧嘧啶片口服治疗,观察组低剂量丙硫氧嘧啶片口服治疗,检测两组患者治疗前后血清甲状腺功能相关指标和肝功能相关指标水平,评价患者甲状腺功能亢进疗效及统计妊娠不良事件发生.结果:两组患者治疗前血清FT3、FT4和TSH水平差异均无统计学意义(P＞0.05),治疗后血清甲状腺功能指标FT3和FT4水平下降、TSH水平升高(P＜0.05),但两组间FT3、FT4和TSH水平无差异(P＞0.05),两组甲状腺功能亢进治疗总有效率无差异(P＞0.05);两组患者治疗前后血清肝功能指标ALP、GGT和TBIL水平较治疗前无差异(P＞0.05),治疗后对照组ALT和AST水平升高,并高于对照组(P＜0.05).观察组妊娠不良事件总发生率(12.8％)低于对照组(22.9％)(x2 =3.958,P=0.000＜0.05).结论:较常规剂量相比,低剂量丙硫氧嘧啶在满足抑制妊娠合并甲亢患者甲状腺功能亢进疗效的基础上,可显著降低对患者肝功能的损伤,减少妊娠不良反应,改善患者妊娠结局.
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