新生儿宫内感染的产前因素与细菌病原体的临床研究

摘要

目的 对新生儿宫内感染的细菌病原体及新生儿发生宫内感染的影响因素进行研究.方法 收集2013～2015年于内江市第二人民医院产检分娩628例产妇的临床资料进行回顾性分析,根据其新生儿是否发生宫内细菌感染分为研究组(86例)和对照组(542例).记录两组年龄、孕次、产次、妊娠期性行为和卫生习惯、妇科炎症、妊娠期检查项目、贫血情况、糖尿病、高血压等患病情况,新生儿宫内细菌感染的发病情况,新生儿宫内感染患者实验室微生物检查结果.分别进行新生儿宫内细菌感染的单因素χ2检验和多因素logistic回归分析.结果 发生新生儿宫内细菌感染86例,发病率为13. 69 %,其中最常见的菌种为大肠埃希菌(30. 23 %),其次是葡萄球菌(16. 28 %),第三位是无乳链球菌(13. 95 %).妊娠晚期有性生活、妊娠期卫生习惯不好、妇科炎症、患有糖尿病的产妇发生新生儿宫内细菌感染的比例较高,差异有统计学意义(P＜0. 05).结论 新生儿宫内细菌感染的主要菌种是大肠埃希菌、葡萄球菌和无乳链球菌,禁止妊娠晚期性生活、注意个人卫生、积极治疗妇科炎症、进行糖尿病的管理都有利于减少新生儿宫内细菌感染的发生.%Objective To study the pathogens of neonatal intrauterine infection and the influencing factors of intrauterine infection in neonates. Methods A total of 628 cases of pregnant women in Neijiang Second People's Hospital from 2013 to 2015 were collected and analyzed retrospectively. Among them, 86 cases of pregnant women had intrauterine infection as the study group and the rest as control group. Record their age, gravidity, parity, pregnancy, sexual behavior and health habits, gynecological inflammation, gestational diabetes, anemia examination, hypertension and other chronic diseases, the incidence of intrauterine infection, patients and results of laboratory microbiological examination of intrauterine infection. Single factor chi square test and multivariate logistic regression analysis were conducted for intrauterine infection. Results In the clinical data of 628 cases collected, a total of 86 cases of intrauterine infection, the incidence of intrauterine infection was 13. 69 %. The most common intrauterine infection were Escherichia coli (30. 23%), followed by Staphylococcus aureus (16. 28%) and Streptococcus agalactiae (13. 95%). In late pregnancy, sexual life, bad pregnancy hygiene habits,gynecological inflammation and women with chronic diseases had higher incidence of intrauterine infection. The differences were statistically significant ( P ＜ 0. 05 ). Conclusion The main strains of intrauterine infection are Escherichia coli, Staphylococcus aureus and Streptococcus agalactiae. Prohibit sexual life in late pregnancy, pay attention to personal hygiene,active treatment of gynecological inflammation and chronic disease management are to reduce intrauterine infection.