Background Retinopathy of prematurity (ROP) threats the visual function of prematurity patients.The screen of ROP is very important for the early prevention and treatment.Some relevant works have performed in several region and cities in China.But the survey data is still lack in Shandong province.Objective This work was to survey and analyze the screening result of ROP in Jinan city and assess the risk factors for ROP.Methods A cross-sectional study was designed.Two hundreds and eighty-eight eyes of 144 cases with low birth weight or prematurity were clinically examined in Shandong Eye Hospital from June,2008 to June,2010.The screening criteria was established based on the ROP screening guidelines and the outcome implemented by Ministry of Public Health with minor modification,including newborn infants with birth weight of 2500 grams or less and gestational age of 34 weeks or less.The history and systemic status were recorded,and the screening results were compared with those obtained from the national screening criteria.Gestation age and birth weight between the infants with and without ROP were compared using student t-test.The ratios of persistent oxygen inhalation were tested by Fisher' s exact test.Results In all examined infants,30 eyes of 15 cases (10.42％) developed ROP,including 12 eyes of 6 cases suffering from stage Ⅰ,8 eyes of 4 cases from stage Ⅱ,8 eyes of 4 cases from stage Ⅲ with plus disease and 2 eyes of 1 case from stage V.In ROP patients,gestation age ranged from 27 weeks to 33 weeks with the average weeks of 30.85±1.79,and the birth weight ranged from 910 grams to 1980 grams with the average weight (1408.89±259.93)grams.Statistical analysis showed that the gestation age and birth weight in prematurity infants with normal fundus group were (32.38±1.48) weeks ranged from 28 weeks to 35 weeks and (1763.19±338.62) grams ranged from 1310 grams to 2450 grams respectively,showing a shorter gestation age (t=3.71,P＜0.01 ) and a lower birth weight ( t =2.88,P＜0.01 ) in ROP infants.The ratios of persistent oxygen inhalation in normal fundus group and ROP group were 58.91％ and 60.00％,respectively with the insignificant difference between them (P =1.000).Conclusions The incidence of ROP is 10.42％ in the present study,which is consistent with the result from other region in China,suggesting that the national criteria is practical for the ROP screening in Jinan region.Prematurity and low birth weight are identified as the high risk factors of ROP.%背景 早产儿视网膜病变(ROP)威胁早产儿的视功能,在早产儿中进行ROP筛查并早期进行干预对保存患儿的视力有着极其重要的意义.目前相关的筛查工作已相继在中国多个地区开展或完成,但山东省济南地区尚缺乏相关的筛查研究.目的 分析山东省济南地区ROP的筛查结果以及相关影响因素.方法 采用横断面调查研究设计.对2008年6月至2010年6月在山东省眼科医院眼底病科就诊且来自山东省济南地区的早产儿和低体重儿144例288眼进行筛查.筛查标准参照2004年中国卫生部颁发的ROP筛查标准和国内多中心的筛查结果,纳入对象为出生体重≤2500 g或矫正胎龄≤34周的早产儿和低体重儿,ROP分类标准采用ROP国际分类标准.检查前询问、记录受检儿的病史并对全身情况进行评估.对ROP患儿组与眼底正常儿组的平均出生孕周和出生体重、患儿有持续吸氧史者所占比例进行统计学分析.结果 本次调查发现,济南地区符合早产儿和低体重儿标准者144例288眼,共筛查出不同程度的ROP患儿15例30眼,其中男8例,女7例；均为双眼患病；ROP检出率为10.42％.ROP患儿出生孕周平均为(30.85±1.79)周;出生体重平均为(1408.89±259.93)g.其中ROP 1期者有6例12眼,2期者4例8眼,3期伴附加病变者4例8眼,5期者1例2眼.受检者中129例眼底正常,出生孕周平均为(32.38±1.48)周,出生体重平均为(1763.19±338.62)g.ROP组患儿的出生孕周明显短于眼底正常组,差异有统计学意义(t=3.71,P＜0.01),ROP组患儿的出生体重明显低于眼底正常组,差异有统计学意义(t=2.88,P＜0.01).眼底正常组与ROP组有持续吸氧史者所占的比例分别为58.91％和60.00％,差异无统计学意义(P=1.000).依据中国卫生部的筛查标准所得的ROP检出率为12.93％(15/116),按山东省的标准检出率为10.42％(15/144),差异无统计学意义(x2=0.398,P=0.528).结论 济南地区ROP检出率与国内其他地区报道的数据较接近.中国卫生部制定的ROP筛查标准适合济南地区的ROP筛查工作.孕周短和出生体重低是导致ROP发生的危险因素.
展开▼
