IgG4 related disease (IgG4-RD) is a systemic disease which was named and accepted in recent years.IgG4-RD is a multiorgan-involved disease, mainly including pancrease, parotid gland, bile duct, liver, etc.The study on the relationship between IgG4 and orbital disease is relatively few.In recent years, our study group aimed directly to the relationship between IgG4 and common orbital disease, including benign lymphoepithelial lesion of lacrimal gland,idiopathic orbital inflammatory pseudotumor, orbital lymphoma, etc.We found that IgG4 was associated with the pathogenesis and progression of these diseases.This article addressed systematically the pathogenesis of IgG4 related orbital disease and evaluated the values of IgG4 in diagnosis,differential diagnosis,treatment and montoring of these orbital diseases based on related literature and reseaching results from our study group,in order to deepen the recognition of IgG4 related orbital diseases in ophthalmologists.%IgG4相关性疾病是近年被国际医学界逐渐认可并接受的一种全身性疾病的统称,其可累及全身多个组织器官,常见的受累器官为胰腺、腮腺、胆管和肝脏等,但目前有关IgG4与眼眶疾病之间关系的研究较为少见.近年来我们课题组主要针对IgG4与泪腺良性淋巴上皮病变、眼眶炎性假瘤、眼眶淋巴瘤等常见眼眶疾病之间关系进行研究,发现上述疾病的发生及发展与IgG4之间存在一定联系.在结合相关文献及我们课题组研究结果的基础上,本文将系统阐述IgG4相关性眼眶疾病的发病机制以及IgG4在IgG4相关性眼眶疾病诊断、鉴别诊断、治疗和预后中的作用,以期提高眼科医师对IgG4相关性眼眶疾病的认识.
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