血小板反应蛋白-1对角膜创伤修复的影响

摘要

Thrombospondin-1 (THBS-1),a kind of extracellular matrix proteins,whose biological action played an important role in corneal wound healing has became a research highlight.The currently research findings showed that THBS-1 could promote the healing of epithelium,stroma and endothelium through activating the transforming growth factor-β1 (TGF-β1) which can accelerate cell proliferation,promote stroma forming and inducing cell migration.It is worthful in clinical treatment of all kinds of corneal wound healing.Now we summarized the research developments which have been acquired in the field recently in this article.%血小板反应蛋白-1 (THBS-1)是一种细胞外基质蛋白,其在角膜创伤修复中发挥的作用是近年来国内外研究的热点.研究发现THBS-1可通过激活转化生长因子-β1(TGF-β1)来促进细胞增生、细胞外基质形成、诱导细胞移行,从而在上皮基底膜、基质层和内皮修复中起重要作用,这将为临床上治疗各种原因引起的角膜创伤开辟新的途径.本文就THBS-1的来源及结构、生物学功能及其在角膜创伤修复过程中所起的作用进行综述.