2005年四省、区的柯萨奇病毒A组16型血清流行病学研究

摘要

目的 了解2005年中国广东、黑龙江、新疆和云南四省、区1～5岁年龄儿童中的柯萨奇病毒A组16型(CVA16)抗体水平,为防控CVA16引起的手足口病的流行提供科学依据.方法 随机挑取上述四省、区2005年1～5岁年龄儿童血清503份进行CVA16的微量中和实验.结果 CVA16抗体阳性率在广东、黑龙江、新疆和云南分别为41.90%、9.40%、40.00%和34.40%.平均抗体滴度(GMT)均较低(平均为1:6.1),广东、黑龙江和云南各省内各年龄组间GMT差异无统计学意义(F值分别为0.97、0.40、1.06,P均>0.05),而四省、区间比较,黑龙江与其他三个省、区GMT差异有统计学意义(F=10.61,P<0.00).结论 2005年或以前CVA16已经在四省、区存在局部流行,但是不同省、区间的CVA16流行传播范围和程度不相同;1～5岁年龄段儿童是CVA16的易感人群.%Objective To study the situation of 1-5 years old children's antibody against Coxsackieviras A group 16 strain( CVA16 )in Guangdong, Heilongjiang, Yunnan Province and Xinjiang Uygur Autonomous Regions, China,2005, it can offer scientific evidences for preventing and controlling CVA16 causative hand-food and mouth disease. Methods Using microneutrilisation test, to study 503 serum samples randomly selected from sera collected in 2005.Resulte. Positive rate of anti-CVA16 antibody were 41.90%, 9.40%, 40.00% and 34.40% in Gnangdong, Heilongjiang, Yunnan and Xinjiang, respectively. Antibody titer was relative low( average, 1:6.1 ) and there was no statistical difference of geometry mean of antibody titer (GMT) among Guangdong, Heilongjiang, Yunnan ( F = 0.97,0.40, 1.06, respectively; P > 0.05 ), while there had statistical difference of GMT between Heilongjiang and other three regions ( F = 10.61, P < 0.00). Conclusions There had probably existed local epidemic in some regions of Gnangdong, Heilongjiang, Yunnan Province and Xinjiang Uygur Autonomous Regions, China, 2005 or even before, but the area and degree of transmission and epidemic had difference. Children aged from 1-5 years old were relatively susceptible population of CVA16 infection.