血浆VEGF水平在维吾尔族妇女子宫内膜癌中表达及意义

摘要

目的 探索血浆血管内皮生长因子(VEGF)在子宫内膜癌中的表达.方法 收集新疆地区50例维吾尔族子宫内膜样腺癌患者血浆,收集40例健康维吾尔族妇女血浆为正常对照.用酶联免疫法测血浆VEGF含量,分析子宫内膜癌同血管内皮生长因子的相关性.分析子宫内膜癌各临床分期及分化程度血浆VEGF的变化状况.结果 子宫内膜样腺癌血浆VEGF水平同正常对照血浆相比差异有统计学意义(P＜0.01);晚期(Ⅲ期、Ⅳ期)子宫内膜样腺癌血浆VEGF增高的水平与早期(Ⅰ期、Ⅱ期)子宫内膜样腺癌相比差异有统计学意义(P＜0.01),在不同分化程度的子宫内膜样腺癌中,随着分化程度的加重,血浆VEGF水平增高,各组相比差异有统计学意义(P＜0.05).结论 子宫内膜癌与血浆VEGF水平增高相关,血浆VEGF水平与临床分期、分化程度相关,临床分期晚的和分化程度低的血浆VEGF水平增高更加明显.%Objective To explore the relationships of serum vascular endothelial growth factor (VEGF) and endometrial cancer of Uighur Women in Xinjiang.Methods The serum of 50 endometrial cancer patient's and 70 healthy women's were collected.VEGF expressions were tested by ELISA method and the correlations of endometrial cancer with VEGF were analysed.The variety of serum VEGF in different clinical stages of endometriat cancer was analyzed.Results Serum VEGF expressions on endometrial cancer were significantly higher than normal ones (P＜0.01);The serum VEGF level in late stage was significantly higher than early stage (P＜0.01).The serum VEGF level significantly increased from well differentiated to the poorly differentiated cases (P＜0.05).Conclusion high level expressions of VEGF are related to the endometrial cancer.Uighur Women in Xinjiang,particularly high expressed in advanced and poorly differentiated endometrial cancer.