Objective To evaluate therapeutic effects of oseltamivir treatment in patients with mild novel influenza A ( H1N1) virus infection through a retrospective analysis.Methods Clinical data of 308 patients with influenza A (H1N1) was collected from 3 infectious diseases hospitals during May-August 2009,after exclusion of non-eligible cases,289 patients were divided into control group and oseltamivir treatment group,the duration of fever and viral load were compared between the 2 groups.Results Influenza A (H1N1) mostly affected 10 to 29-year-old persons,fever was the most common symptom which was low or moderate-level( ＜ 39 ℃ ),other symptoms involved sore throat,cough,headache,and rhinorrhea,a few patients had vomiting (1.3％)and diarrhea( 3.9％ ).Finally,there was no significant difference in duration of virus shedding from illness onset or beginning of therapy among the 2 groups(P =0.32,0.93 ).Conclusion The adolescents were main target of influenza A (H1N1) virus,most patients appeared to experience mild disease with better prognosis.For mild patients,oseltamivir could not shorten duration of fever and virus shedding effectively,and the virus could be cleared rapidly by immune system.Oseltamivir treatment had no clinical significance for mild influenza patients.%目的 通过回顾性分析系统评价奥司他韦(达菲)对新型甲型H1N1流感轻症病例的临床治疗效果.方法 收集2009年5-8月国内三家传染病医院的308例甲型H1N1流感住院患者的临床资料,了解甲型H1N1流感的年龄分布特征及主要临床特征,之后剔除不符合要求的研究对象,将289例甲型H1N1流感轻症患者分为对照组和达菲组,了解两组病例在发热持续时间以及病毒持续时间的差异.结果 甲型H1N1流感患者的发病年龄主要集中在10～29岁.发热是甲型H1N1流感的最主要症状,以低、中度发热(＜39℃)为主,咽喉疼痛、咳嗽、头痛、流涕也是常见症状,但呕吐及腹泻患者比例较少,分别为1.3％和3.9％.最后对照组和达菲组在发病-病毒转阴时间和治疗-病毒转阴时间上的差异均无统计学意义(P =0.32,0.93).结论 甲型H1N1流感发病以青少年为主,多数患者病情较轻,预后良好.对于甲型H1N1流感轻症患者而言,达菲并不能有效缩短发热持续时间及病毒持续时间,流感病毒可以迅速被机体自身免疫系统清除,对轻症患者使用达菲抗病毒治疗并无临床意义.
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