目的 探讨血清尿酸水平对老年慢性心力衰竭患者预后的影响.方法 连续入选2014年1月~2015年6月就诊于苏州市立医院北区心血管内科的老年慢性心力衰竭患者258例,其中男性118例,女性140例.根据入院血清尿酸水平分为对照组(121例)和高尿酸组(137例),收集患者既往病史、实验室检查等临床资料,并随访一年.结果 与对照组比较,高尿酸组肌酐、尿酸、脑钠肽(BNP)明显升高,差异有统计学意义(P均<0.05).随访1年结果发现,肾功能不全、新发房颤、高钾血症的发生率高尿酸组明显高于对照组,32.85%vs.17.36%,11.68%vs.4.13%,9.45%vs.2.45%,差异有统计学意义(P均<0.05).结论 血清尿酸升高的老年慢性心力衰竭患者肾功能不全、新发房颤、高钾血症发生率升高,预后不良.%Objective To discuss the influence of level of serum uric acid (UA) on prognosis in elderly patients with chronic heart failure (CHF).Methods CHF patients (n=258, male 118 and female 140) were continuously chosen from the Northern Area of Department of Cardiovascular Diseases of Suzhou Municipal Hospital from Jan. 2014 to Jun. 2015. All patients were divided, according to level of serum UA, into control group (n=121) and high UA group (n=137). The clinical data were collected including past medical history and laboratory test indexes, and all patients were followed up for 1 y.Results The levels of serum creatinine (SCr), UA and B-type natriuretic peptide (BNP) increased significantly in high UA group compared with control group (allP<0.05). After followed up for 1 y, the incidence rates of renal insufficiency (32.85%vs. 17.36%), new-onset atrial fibrillation (11.68%vs. 4.13%) and hyperkalemia (9.45%vs. 2.45%) were significantly higher in high UA group than those in control group (allP<0.05).Conclusion The incidence rates of renal insufficiency, new-onset atrial fibrillation and hyperkalemia are higher and prognosis is poor in CHF patients with higher level of serum UA.
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