Objective To compare the changes of urinary iodine levels among the family members with iodine content of 5-150 μg/L in drinking water, before and after non-iodized salt intervention through a field trail study. Methods Family members who routinely drank water with iodine content 5-150μg/L were chosen to substitute non-iodized salt for their current iodized salt for 2 months, and urine samples of the family members were collected for determination of iodine change before and after intervention was carried out. Results Median urinary iodine of school children, womcn with productive age and male adults exceeding 370 μg/L before intervention and the frequency distribution of urinary iodine were all above 70%. Our results revealed that iodine excess exited in three groups of family members. After intervention,all median urinary iodine level seemed to have decreased significantly, and groups with drinking water iodine 5.0-99.9 μg/L reduced to adequate or close to adequate while the group that drinking water iodine was 100-150 μg/L reached the cut-off point of excessive iodine level (300 μg/L). Conclusion Results from your study posed the idea that the iodine adequate areas should be defined as the areas with iodine content of 5.0-100 μg/L in drinking water, and edible .salt not be iodized in these areas. Areas with iodine content of 100-150 μg/L in drinking water should be classified as iodine excessive.%目的 通过现场干预试验,对比观察饮用水碘含量为5～150μg/L人群停供碘盐前后碘营养水平的变化.方法 选择生活饮用水碘含量5～150μg/L的居民户作为目标居民户,用无碘盐替换其家中正在食用的碘盐,干预60 d后采集家庭成员尿样.结果 干预前学龄儿童、育龄妇女、成年男子的尿碘中位数均在370μg/L以上,频数分布≥300 μg/L的比例均在70%以上,三类人群的碘营养状况处于碘过量水平.干预后三类人群的尿碘中位数均较干预前明显下降,其中生活饮用水碘含量为5.0～99.9μg/L的人群碘营养水平下降到碘营养适宜水平或基本适宜水平;生活饮用水碘含量为100～150μg/L时,三类人群干预后的尿碘中位数仍接近300 μg/L,处于碘营养偏高状态.结论 生活饮用水水碘含景为5～100μg/L的地区为适碘地区,不需要供应碘盐;生活饮用水水碘含量为100～150μg/L的地区应划分为高碘地区.
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