128例克林霉素磷酸酯不良反应中文文献分析

摘要

目的:分析克林霉素磷酸酯不良反应的发生特点和临床表现,为临床合理用药提供参考.方法:通过中国知网(CNKI)中国医院数字图书馆CHKD期刊全文数据库检索1998年12月–2017年3月有关克林霉素不良反应.对患者性别、年龄、用药剂量及溶媒、ADR发生时间、原发疾病、联合用药及不良反应表现等进行统计分析.结果:共检索出87篇文献,128例.原发疾病以上呼吸道感染最多,为55例(43.0%);所有不良反应中,发生过敏性休克32例,死亡1例.结论:在临床应用过程中,克林霉素磷酸酯的不良反应临床表现复杂,严重者可致死亡.%Objective: To analyze the characteristics and clinical manifestations of adverse reactions induced by clindamycin phosphate, and provide reference for rational drug use in clinic. Methods: Through the China Hospital Knowledge Database (CHKD) journal full-text database of China National Knowledge Infrastructure (CNKI), adverse reactions related to clindamycin were retrieved from December 1998 to March 2017. The patient's gender, age, drug dosage and solvent, ADR occurrence time, primary disease, drug combination, and the performances of adverse reactions were analyzed statistically. Results: A total of 87 articles involved 128 cases were searched. The main primary disease was respiratory tract infection, accounting for 43.0%(55 cases). There were 32 cases of anaphylactic shock, 1 case of death. Conclusion: In the process of clinical application, clinical manifestations of adverse reaction induced by clindamycin phosphate were complex, and the severe cases could cause death.