目的：探讨我院ADR的发生规律和特点，为临床安全合理用药提供参考。方法：采用回顾性研究方法，提取我院2012年1月–2015年12月上报的997例ADR报告数据，并对患者年龄、药品种类、给药途径、ADR累及系统/器官及主要临床表现等进行统计分析。结果：997例ADR报告中，男性患者472例（47.35%）；女性患者525例（52.65%）；以45岁以上人群居多（64.30%）；发生ADR药品抗感染药物居首位（21.66%）；以静脉滴注（64.59%）给药途径为主；ADR累及系统/器官主要涉及皮肤（32.50%）和神经系统（26.37%）。结论：ADR发生与多种因素有关，建议临床应合理使用各类药物，重视不良反应监测，以降低不良反应的发生率。%Objective: To study the characteristics of adverse drug reaction (ADR) in our hospital, in order to provide references for clinical safe and reasonable use of medication.Methods:With the retrospective method, all the 997 ADR reports were extracted from our hospital from January 2012 to December 2015. The data in respect of patients' age, drug types, route of administration, systems/organs involved in ADR and clinical manifestations were analyzed statistically.Results: Among the 997 ADR reports, the number of male patients and female patients were 472 cases (accounting for 47.35%) and 525 cases (accounting for 52.65%), respectively. The proportion of patients who were more than 45 years old was 64.30%, and anti-infective agents ADRs accounted for 21.66%. The majority administration route was intravenous infusion (64.59%). The majority systems and organs involved in ADR were skin (32.50%) and nervous system (26.37%). Conclusion: The multiple factors may lead to high frequency of ADR. Consequently, great attentions should be paid to the rational use of various drugs and monitoring of ADRs for reducing the incidence of ADR.
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