目的 研究急性有机磷农药中毒(AOPP)发生中枢性尿崩症(CDI)、高血糖及其对预后的影响.方法 回顾AOPP患者32例临床资料,分析发生尿崩症、高血糖的情况,观察比较不同并发症患者的预后.结果 并发CDI的6例患者全部死亡,病死率100%,CDI与非CDI患者血生化、尿比重比较,除BUN外差异均有统计学意义(P<0.05);并发高血糖13例患中,死亡7例,病死率53.8%,高血糖与非高血糖患者比较,血渗透压、尿比重比较,差异均有统计学意义(P<0.05).随血糖水平升高,病死率呈增高趋势,血糖>14.0 mmol/L者病死率较血糖≤14.0 mmol/L者病死率明显升高,差异有统计学意义(P<0.05).结论 AOPP患者合并中枢性尿崩症或高血糖者病死率极高,近期预后差.%Objective To investigate prognostic significance of acute organophosphorus pesticides poisoning ( AOPP ) with central diabetes insipidus ( CDI ) and hyperglycemia. Methods The clinical data of 32 patients with AOPP were analyzed retrospectively, prognosis was compared between patients with CDI and hyperglycemia. Results 6 patients combined with CDI were all dead and the mortality was 100% , there were significant differences between patients with and without CDI on blood biochemical indexes and urine specific gravity except BUN( P <0. 05 );7 cases out of 13 patients combined with hyperglycemia were dead and the mortality was 53. 8% , there were significant difference between patients with and without hyperglycemia on blood osmotic pressure and urine specific gravity( P < 0. 05 ). The mortality showed an increase tendency along with the level of blood glucose, the mortality in patients with blood glucose > 14. 0 mmol/L was higher than those ≤ 14. 0 mmol/L, there was significant difference( P <0.05 ). Conclusion Mortality was high with CDI or hyperglycemia in AOPP, and had unfavorable prognosis.
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