Objective To analyze the etiological causes,clinical manifestations,laboratory characteristcs and diagnosis criterions with Cushing' s syndrome,in order to improve the early diagnosis of this disease.Methods Collected and reviewed the clinical data of 24 cases with Cushing' s syndrome admitted to the hospital from Jan 2007 to Dec 2012.Results Cushing' s disease and adrenal adenoma were common.Hypertension were the most frequent signs,account for 83.33％ patients(20/24).The prevalence of abnormal glucose metabolism and hypokalemia were 54.17％ (13/24) and 37.50％ (9/24),respectively.Purple stripes,ecchymosis and acne were rare signs.In the screening tests,all cases with endogenous Cushing' s syndrome can be suppressed from low dose dexamethasone suppression test.5 out of 7 patients with Cushing' s disease can be suppressed from high dose dexamethasone suppression test,and MR of the pituitary in 5 cases exhibits pituitary adenoma.CT of the adrenal glands all exist positive findings.Conclusion The prevalence of hypertension and diabetes are high in patients with Cushing' s syndrome.High dose dexamethasone suppression test,adrenocorticotropic hormone combined with imaging findings are necessary for the differential diagnosis of Cushing' s syndrome.%目的 探讨库欣综合征患者的病因、临床表现、实验室检查、诊断方法等,提高该病的早期诊断水平.方法 收集2007年1月-2012年12月24例库欣综合征患者的完整临床资料,进行回顾性分析.结果 该组病例主要病因为库欣病和肾上腺皮质腺瘤.临床表现以高血压出现频率最高(83.33％,20/24),糖代谢异常和低血钾分别为54.17％(13/24)和37.50％ (9/24),紫纹、瘀斑、痤疮少见.诊断试验方面,20例内源性库欣综合征患者均不被小剂量地塞米松抑制,7例库欣病患者中5例能被大剂量地塞米松抑制.5例垂体MR示微腺瘤,肾上腺肿瘤患者的肾上腺CT均有阳性发现.结论 库欣综合征临床表现迥异,患者高血压、糖代谢异常的发生率均较高.大剂量地塞米松抑制试验、促肾上腺皮质激素水平联合影像学检查对病因诊断至关重要.
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