脑梗死患者血清 ox－LDL、CRP、MMP－9水平与颈动脉弹性的相关性研究

摘要

目的：分析脑梗死患者血清氧化低密度脂蛋白（ ox－LDL）、C反应蛋白（ CRP）、基质金属蛋白酶－9（MMP－9）与颈动脉弹性指标的相关性。方法选取2015年1—12月动脉粥样硬化性脑梗死（ACI）患者110例（ACI组）、腔隙性脑梗死（ LACI）患者90例（ LACI组）和健康人群100例（健康对照组），检测血清ox－LDL、CRP和MMP－9水平，颈动脉压力应变弹性系数（Ep）、僵硬度（β）、顺应性（AC）、增大指数（AI）及脉搏波传导速度（PWVβ），分析上述指标之间的相关性。结果（1）与健康对照组比较，LACI组Ep、β、AI、PWVβ值增高，MMP－9、ox－LDL、CRP水平增高，AC降低，差异有统计学意义（ P ＜0．01）；与LACI组比较，ACI组Ep、β、AI、PWVβ值增高，MMP－9、ox－LDL、CRP水平增高，AC降低，差异有统计学意义（ P ＜0．01）。而各组间TC、TG、FPG均无明显差异（ P ＞0．05）。（2）脑梗死患者血清ox－LDL、CRP、MMPs－9水平与β、PWVβ呈正相关（ r ＝0．346、0．305，0．686、0．835，0．664、0．712， P均＜0．01）。结论脑梗死患者血清ox－LDL、CRP和MMP－9与颈动脉β、PWVβ有明显相关性，三者均是早期发现动脉弹性病变的敏感指标。%Objective To analyze the correlation between cerebral infarction patient ’ s serum oxidized low density lipoprotein (ox-LDL), C-reactive protein (CRP), matrix metalloproteinase 9 (MMP-9) and carotid artery elasticity index. Methods From 2015 January to December , 110 cases of atherosclerotic cerebral infarction ( ACI) patients were enrolled as ACI group, 90 cases of lacunar cerebral infarction (LACI) patients were enrolled as LACI group , and 100 cases healthy peo-ple enrolled as healthy control group , detected level of serum ox-LDL, CRP, MMP-9, carotid artery pressure strain elastic co-efficient (Ep), stiffness (β), compliance (AC), increase index (AI) and pulse wave velocity (PWVβ), and analyzed the correlation between these indices .Results (1) compared with the healthy control group , LACI group’ s Ep,β, AI, PWVβvalues were increased , MMP-9, ox-LDL, CRP levels were increased , AC were decreased , the difference were statistically sig-nificant ( P <0.01);compared with the LACI group, the ACI group’s Ep,β, AI, PWVβvalues were increased, MMP-9, ox-LDL, CRP levels were increased, AC was decreased, the difference were statistically significant ( P <0.01).There were no significant difference of TC, TG, FPG among different groups ( P >0.05).(2) Cerebral infarction paitents’ serum level of ox-LDL, CRP, MMP-9,β, PWVβwere positively correlated ( r =0.346, r =0.305, r =0.686, r =0.835, r =0.664, r =0.712, all P <0.01).Conclusion Cerebral infarction patients ’ ox-LDL, CRP, MMP-9,β, PWVβwere significantly correlated, these indices can be used as a sensitive indicator to early detect of arterial elasticity related diseaes .