Objective To explore the effect of haloperidol combined with Clonidine transdermal patch for the treat -ment of refractory Tourette syndrome and Th 1/Th2.Methods Between December 2013 and March 2015, 40 children with re-fractory Tourette syndrome treated in Cangzhou Central Hospital of Hebei province were selected as study subjects ( observation group) .Another 40 cases of healthy children were selected as healthy control group .Was given to the observation group with haloperidol combined with clonidine transdermal patch for treatment , before and after the treatment by the Yale Global Tic Se-verity Scale ( YGTSS) , attention deficit hyperactivity disorder ( ADHD) were used to assess the symptom score , the level of serum IFN gamma, IL-4, IL-13 and IFN gamma, IL-4, IL-13 and YGTSS score, ADHD score correlation analysis was carried out.Results After treatment, the YGTSS scores and ADHD scores were significantly lower ( P <0.05) than before treat-ment.Before treatment, observation group IFN gamma, IL-13 levels were higher than those in healthy control group ( P <0.05) and IL-4 levels lower than that of healthy control group; after treatment, serum IFN gamma, IL-4, IL-13 level com-pared with those before treatment significantly improved , the differences were statistically significant ( P <0.05).IFN gam-ma levels with YGTSS score, ADHD score were positively correlated ( r =0.312, P =0.007;r =0.305, P =0.011);IL-4 levels and YGTSS score, ADHD score showed a negative correlation ( r =-0.317, P =0.004; r =-0.302, P =0.014);IL-13 level with YGTSS score, ADHD score were positively correlated ( r =0.306, P =0.011;r =0.291, P =0.021).No serious adverse reactions occurred in children .Conclusion Clonidine transdermal patch combined haloperidol in the treatment of refractory Tourette syndrome can improve clinical symptoms , and high safety .%目的：观察氟哌啶醇联合可乐定透皮贴剂治疗难治性Tourette综合征及对Th1／Th2的影响。方法选择2013年12月—2015年3月在河北省沧州市中心医院儿童保健科诊治的难治性Tourette综合征患儿40例为研究对象（观察组）。另选择同期体检健康儿童40例作为健康对照组。观察组患儿给予氟哌啶醇联合可乐定透皮贴剂治疗，治疗前后采用耶鲁抽动严重程度评估量表（ YGTSS）、注意力缺陷多动障碍（ADHD）评分进行症状评定，检测血清中IFN-γ、IL-4、IL-13的水平，并对IFN-γ、IL-4、IL -13与YGTSS评分、ADHD评分进行相关性分析。结果治疗后，患儿YGTSS各项评分及ADHD各项评分均较治疗前降低（ P ＜02．05）。治疗前，观察组IFN-γ、IL-13水平均高于健康对照组（ P ＜0．05），IL-4水平低于健康对照组；治疗后，血清IFN-γ、IL-4、IL-13水平较治疗前明显改善，差异均有统计学意义（P ＜0．05）。 IFN-γ水平与YGTSS评分、ADHD评分均呈正相关（ r ＝0．312、P ＝0．007；r ＝0．305、P ＝0．011）；IL-4水平与YGTSS 评分、ADHD评分均呈负相关（ r ＝－0．317， P ＝0．004；r ＝－0．302， P ＝0．014）；IL-13水平与YGTSS评分、ADHD评分均呈正相关（ r ＝0．306， P ＝0．011；r ＝0．291， P ＝0．021）。患儿未出现严重不良反应。结论氟哌啶醇联合可乐定透皮贴剂治疗难治性Tourette综合征可有效改善临床症状，且安全性高。
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