Objective To investigate the relationship between the fatty acid binding protein 4 (FABP4), fibroblast growth factor 21 (FGF21), food intake inhibitor 1 (Nesfatin-1) and insulin resistance (IR) in patients with gestational diabe-tes mellitus (GDM).Methods Sixty GDM patients and thirty healthy cases were enrolled in this study.The serum levels of FABP4, FGF21, Nesfatin-1 and index of IR were measured and analyzed.Results GDM group serum FABP4, FGF21, Nes-fatin-1 levels were significantly higher[FABP4: (27.49 ±3.72) μg/L vs.(18.98 ±5.51) μg /L, t =2.585, P <0.05;FGF21 :(198.14 ±13.53) ng/L vs.(102.4 ±19.7) ng /L, t =2.137, P <0.05; Nesfatin-1: (2.49 ±0.72) μg/L vs. (1.98 ±0.51) μg /L, t =2.361, P <0.05〗.GDM patients HOMA-IR, HOMA-β, PGAUC, INSAUC /PGAUC, △I30 /△G30 levels were significantly higher ( HOMA-IR: 3.89 ±1.12 vs.2.05 ±0.54, t =2.362, P <0.05; HOMA-β:112.63 ±29.52 vs.169.72 ±42.14, t =2.809, P <0.05; PGAUC: 20.55 ±2.21 vs.13.98 ±1.66, t =2.697, P <0.05; INSAUC /PGAUC: 8.23 ±3.12 vs.10.92 ±2.91, t =2.133, P <0.05; △ I30 /△ G30:15.66 ±5.49 vs.22.12 ± 3.34, t =2.249, P <0.05).FABP4, FGF21, Nesfatin-1 was positively correlated with HOMA-IR ( r =0.402, 0.374, 0.398, P <0.05), and HOMA-βnegative correlation ( r =-0.435, -0.335, -0.376, P <0.05).Conclusion The ser-um levels of FABP4, FGF21, Nesfatin-1 were significantly increased in GDM patients, and there was a certain correlation be-tween and IR.%目的：探讨脂肪酸结合蛋白4（FABP4）、成纤维细胞生长因子21（FGF21）、摄食抑制因子－1（Nesfatin－1）与妊娠糖尿病（GDM）患者胰岛素抵抗（IR）的关系。方法选取2013年1月—2015年12月胶州中心医院妇产科收治的60例 GDM 患者（GDM 组）和30例健康孕妇（对照组）为研究对象，检测血清 FABP4、FGF21、Nesfatin－1水平和IR 相关指数，并分析比较它们之间的关系。结果GDM 组患者血清 FABP4、FGF21、Nesfatin－1水平均明显高于对照组[FABP4（27．49±3．72）μg／L vs．（18．98±5．51）μg／L， t ＝2．585， P ＜0．05；FGF21：（198．14±13．53） ng／L vs．（102．4±19．7） ng／L， t ＝2．137， P ＜0．05；Nesfatin－1（2．49±0．72）μg／L vs．（1．98±0．51）μg／L， t ＝2．361， P ＜0．05]。GDM 组患者 HOMA－IR、 HOMA－β、PGAUC、INSAUC／PGAUC、△I30／△G30水平均明显高于对照组（HOMA－IR 3．89±1．12 vs．2．05±0．54， t ＝2．362， P ＜0．05；HOMA－β112．63±29．52 vs．169．72±42．14， t ＝2．809， P ＜0．05；PGAUC 20．55±2．21 vs．13．98±1．66， t ＝2．697， P ＜0．05；INSAUC／PGAUC 8．23±3．12 vs．10．92±2．91， t ＝2．133， P ＜0．05；△I30／△G3015．66±5．49 vs．22．12±3．34， t ＝2．249， P ＜0．05）。 FABP4、FGF21、Nesfatin－1与 HO－MA－IR 呈正相关（ r ＝0．402、0．374、0．398， P ＜0．05），与 HOMA－β呈负相关（ r ＝－0．435、－0．335、－0．376， P ＜0．05）。结论GDM 患者血清 FABP4、FGF21、Nesfatin－1水平明显上升，且与 IR 存在一定的相关性。
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