慢性阻塞性肺疾病稳定期患者血清镁、钙和维生素D水平与生活质量的相关性分析

摘要

目的 分析慢性阻塞性肺疾病(COPD)稳定期患者血清镁、钙和维生素D水平与生活质量的相关性.方法 选择2015年6月-2016年6月西安市第一医院呼吸科、老年科诊治的COPD稳定期患者110例(观察组)作为研究对象,检测血清镁、钙和维生素D水平,并进行慢性阻塞性肺病评估测试(CAT评分)、呼吸困难评分(mMRC指数)和BODE指数,以及二者的相关性.结果 观察组与健康对照组患者在血清镁、血清钙和血清25(OH)D3水平方面比较差异无统计学意义(P>0.05).低镁、钙、维生素D血症组患者BODE指数、mMRC指数和CAT评分均明显高于非低镁、钙、维生素D血症亚组患者(P<0.05).血清镁、血清钙、维生素D与mMRC 、BODE指数和CAT评分均呈明显负相关(P<0.05).结论 血清镁离子、钙离子和维生素D水平与COPD患者生活质量密切相关.%Objective To evaluate the correlation between serum magnesium,calcium,vitamin D and quality of life in patients with COPD.Methods One hundred and ten COPD patients were enrolled in this study from June 2015 to June 2016 in Department of Respiratory and Department of Geriatrics of Xi'an First Hospital.The levels of serum magnesium,calcium,vitamin D were measured.CAT score,mMRC score and BODE index were used as life quality criteria.Results There was no statistical difference between the observed group and the control group in serum magnesium,serum calcium and serum 25 (OH) D3 levels (P<0.05).Low magnesium,calcium,vitamin D levels and the group of patients with an average duration,serum calcium,magnesium,serum 25 (OH) D3 level and the low magnesium,calcium,vitamin D levels had no significant difference (P>0.05),low magnesium,calcium,vitamin D levels patients' BODE index,mMRC rating and CAT scores were significantly higher than the non-low magnesium,calcium,vitamin D levels patients (P<0.05).Correlation analysis showed serum magnesium was negatively associated with mMRC,BODE index and CAT score.Conclusion Serum magnesium,calcium and vitamin D are related with quality of life in patients with COPD.