肥胖型2型糖尿病与阻塞性睡眠呼吸暂停低通气综合征

摘要

The study found that obstructive sleep apnea is closely related with obesity, impaired glucose tolerance and type 2 diabetes. Obesity can cause fatty deposition of lower mandible and circumthroat and upper airway constriction. The chest and abdominal fat accumulation can result in lung capacity drop. In addition, obesity can reduce insulin sensitivity and insulin receptor amount, which finally results in impaired carbohydrate tolerance and diabetes.%研究发现阻塞性睡眠呼吸暂停与肥胖、葡萄糖耐受不良以及2型糖尿病密切相关.肥胖易引起下颌及咽周脂肪沉积,上气道狭窄塌陷,并且胸腹壁脂肪增多,引起肺容量下降;另外,肥胖可使胰岛素敏感性下降,胰岛素受体数量减少,引起胰岛素抵抗,最终导致糖耐量减低和糖尿病的发生.