1，5-脱水葡萄糖醇与2型糖尿病患者尿白蛋白水平的相关性研究

摘要

目的：探讨1，5‐脱水葡萄糖醇（1，5‐AG）与 T2DM 患者UAlb水平相关性。方法选取住院T2DM患者411例，根据HbA1 c水平分为≤7％组81例和＞7％组330例，另根据24 hUAlb将两组各分为＜30 m g／24 h亚组及30～299 m g／24 h亚组，检测相关生化指标及1，5‐A G水平。结果在HbA1 c≤7％组中，UAlb 30～299 mg／24 h亚组1，5‐AG 低于 UAlb＜30 mg／24 h亚组[17.3（12.34，23.83） vs 10.40（7.20，13.78）μg／ml ，P＜0.05]；在HbA1 c＞7％组中，两亚组1，5‐AG水平比较，差异无统计学意义[2.67（1.26，6.35） vs 2.44（1.22，5.30）μg／ml ，P＞0.05]。结论在HbA1c≤7％的T2DM患者中，1，5‐AG可能是UAlb水平的相关因素。%Objective To investigate the correlation between the level of serum 1 ,5‐anhydroglucitol (1,5‐AG)andUAlbinpatientswithT2DM.Methods 411hospitalizedpatientswithT2DMwere recruited and divided into two groups according to the levels of HbA 1 c:≤ 7% or >7%. Each group was divided into two subgroups according to the levels of 24 hUAlb:UAlb<30 mg/24 h subgroup and 30~299 mg/24 h subgroup. HbA1c ,serum 1 ,5‐AG ,UAlb and biochemical indexes were tested and compared. Results In HbA1 c ≤ 7% group ,1 ,5‐AG level in 30~299 mg/24 h subgroup was lower than in <30 mg/24 h subgroup [17.30(12.34 ,23.83) vs 10.40(7.20 ,13.78)μg/ml ,P< 0.05];In HbA1c> 7% group ,there was no difference in the level of 1 ,5‐AG between two subgroups [2.67(1.26 ,6.35) vs 2.44(1.22 ,5.30)μg/ml ,P>0.05]. Conclusion In T2DM patients with HbA1 c ≤7% ,1 ,5‐AG may be the risk factor of increased urinary microalbumin.