左旋肉毒碱与2型糖尿病

摘要

T2DM的发生与发展均与能量代谢异常有关,左旋肉毒碱作为近年来备受重视的改善能量代谢的药物之一,可通过防止细胞脂质过氧化、清除自由基抗氧化、促进长链脂肪酸进入线粒体内进行β-氧化、增加脂质代谢等作用对糖尿病多个并发症起到有益作用并能逆转IR,降低FPG水平.左旋肉毒碱在T2DM的进展中发挥一定的抑制作用,早期对其进行干预可改善T2DM及其并发症的进展,为T2DM的治疗提供新思路.%The occurrence and development of type 2 diabetes mellitus(T2DM) are related to abnormal energy metabolism.L-carnitine,as one of the most important drugs to improve energy metabolism,has gradually been in a hot research in recent years.It can prevent cell lipid peroxidation,prevent oxidation by free radical scavenging,promote long-chain fatty acids into mitochondria for β-oxidation and increase lipid metabolism and improving diabetic complications.It can also decrease insulin resistance (IR),and lower fasting blood glucose (FBG).L-carnitine may have certain inhibitory effect on the development of T2DM.Early application of L-carnitine may improve the complication of T2DM diabetes,and provide a new way for the treatment of T2DM.