Objective To investigate the features of female sexual dysfunction (FSD) in type 2 diabetic patients (T2DM)and to analyze its risk factors. Methods According to FSFI indexes in the sexual function questionnaire,227 female T2DM patients were divided into DM group without FSD [n=144,FSFI≥25] and DM+FSD group[n=83,FSFI<25]. 80 healthy women served as normal controls. The risk factors for FSD were analyzed using logistic regression analysis. Results The occurrence of FSD was 36.6%(83/227) in female T2DM patients. The levels of FSH,TSTO and LH were higher,and E2 was lower in DM+FSD group and DM group than those in NC group(P<0.01),but there was no statistical significance between DM+FSD group and DM group(P>0.05). The score of sexual desire[(2.54±0.58) vs (3.76±0.90) vs (4.59±1.22) score],sexual arousal[(2.30±0.42) vs (3.57±0.85) vs (4.81±1.00) score],vaginal lubricate[(3.35±0.29) vs (4.46±1.32) vs (5.14±0.83) score],orgasm[(2.75±0.68) vs (3.40±1.86) vs (4.02±1.25)score] and total score [(17.94±4.15) vs (24.71±6.33) vs (28.13±5.78) score] were lower in DM+FSD group and DM group than those in NC group. The score of sexual satisfaction[(3.45±1.68) vs (4.94±0.93),(4.99±0.86)score] and pain[(3.55±0.50) vs (4.58±0.47),(4.58±0.62)score] were lower in DM+FSD group than those in DM group and NC group(P<0.05),but there was no statistical significance between DM group and NC group(P>0.05). Logistic regression analysis showed that age,BMI and HbA1c were risk factors for FSD in T2DM patients (P=0.029,0.001,0.022,respectively). Conclusion The occurrence of FSD is common in female type 2 diabetic patients. BMI and HbA1c are the main risk factors for FSD.%目的 探讨T2DM女性患者性功能障碍的特点,并分析其发生的危险因素. 方法 选取T2DM女性患者227例,根据是否伴女性性功能障碍(FSD)分为单纯糖尿病组(DM)组[女性性功能指数问卷(FSFI)评分≥25]144例和糖尿病FSD组(DM+FSD组,FSFI评分<25)83例,另选取同期于我院体检中心体检健康女性80名作为健康对照(NC)组.采用FSFI问卷评估各组性功能,Logistic回归分析糖尿病女性患者伴FSD的危险因素. 结果 T2DM女性患者中,FSD的发生率为36.6%(83/227);与NC组比较,DM+FSD组和DM组卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(TSTO)升高,雌二醇(E2)降低(P<0.01);DM+FSD组与DM组比较,差异无统计学意义(P>0.05);与NC组比较,DM组和DM+FSD组性欲[(4.59±1.22) vs (3.76±0.90) vs (2.54±0.58)分]、性唤起[(4.81±1.00) vs (3.57±0.85) vs (2.30±0.42)分]、阴道润滑[(5.14±0.83) vs (4.46±1.32) vs (3.35±0.29)分]、性高潮[(4.02±1.25) vs (3.40±1.86) vs (2.75±0.68)分]4个维度评分及总分[(28.13±5.78) vs (24.71±6.33) vs (17.94±4.15)分]均降低(P<0.05或P<0.01).DM+FSD组性满意度[(3.45±1.68) vs (4.94±0.93)、(4.99±0.86)分]和性疼痛[(3.55±0.50)、(4.58±0.47) vs (4.58±0.62)分]2个维度评分低于DM组和NC组(P<0.05),DM组和NC组比较,差异无统计学意义(P>0.05);Logistic回归分析显示,年龄、BMI及HbA1c为糖尿病伴FSD的危险因素(P=0.029、0.001、0.022). 结论 糖尿病FSD的发生率较高,年龄、BMI、HbA1c是其主要危险因素.
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