Sepsis, a leading cause of death in patients with critical illness, has been defined as a syndrome mainly characterized by a systemic inflammatory response induced by suspected or proven infection. Nowadays, there is no effective measures for prevention and treatment of sepsis patients. Hyperoxia inhalation as a therapeutic tool has been widely used in clinical practice. But its clinical application is limited because of oxygen toxicity. However, some recent studies have reported that early ventilation with high concentrations of oxygen can improve survival rate and organ function. And some recent studies have found that moderate amounts of ROS have beneficial effect on the generation and development of diseases.%脓毒症(sepsis)是一种由感染因素诱发、以全身炎症反应为主的综合征,是危重病患者的主要死因之一.目前尚无有效的防治措施,高氧吸入作为一种治疗手段已被广泛应用于临床,但因为氧毒性,其临床应用受限.然而,近年来研究发现,早期给予高浓度氧气吸入可有效地保护多种休克动物器官功能,显著提高休克动物存活率,且适量的活性氧族(ROS)对疾病的发生、发展发挥有利的作用.
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