环境因素对呼出气一氧化氮的影响

摘要

呼出气一氧化氮( FeNO )被认为是检测哮喘和呼吸道变态反应引发的气道炎症的一种非侵袭性生物标记物环境因素，特别是室内和室外空气质量可能在诱发呼吸道症状急性加重中扮演了重要的角色。城市和工业污染，主要是颗粒物(PM2.5和PM10)，二氧化氮(NO2)，二氧化硫(SO2)，甲醛(formaldehyde)会引起FeNO升高。虽然还需要更多的相关研究来进一步确定FeNO用来管理哮喘的价值，临床医生推荐应考虑环境因素对哮喘和呼吸道变态反应患者的影响。进一步的研究应该波及在治疗时减少环境暴露因素对这些疾病的影响。%Fractional exhaled nitric oxide(FeN O )is a non-invasive biom arker of airw ay inflam m ation caused by asth-m a and respiratory allergy.Environm ental factors,especially indoor and outdoor air quality,m ay play an im portant role in triggering acute exacerbations of respiratory sym ptom s.A lthough the findings are not consistent,urban and industrial pollution-m ainly particulate m atters(PM 2.5 and PM 10),nitrogen dioxide (N O 2),and sulfur dioxide(SO 2)-as w ell as form alde-hyde can cause FeN O increase.A lthough m ore studies are needed in order to better investigate the effect of environ-m ent interactions w hich m ay affect the interpretation of FeN O values in the m anagem ent of sufferers w ith asthm a,clini-cians recom m end to consider the influence of environm ental factors on asthm a and respiratory allergy.Further research should involve in how to reduce the influence of environm ental exposure factors on asthm a and respiratory allergy in their treatm ent.