温敏型壳聚糖介入核素188Re内照射抗小鼠移植性肝癌(H22)

摘要

Objectives To study the inhibitory activity of internal irradiation of interventional radionuclide 188 Re in thermosensitive chitosan on mouse transplanted tumor H22 (liver cancer).Method The tumor-bearing mice were divided into 7 groups randomly, including model control, 188Re(0.1mCi) group, 188Re-S(0.1mCi) group, 188Re + CS(0.1mCi)group, 188Re + CS (0.2mCi)group, 188Re-S + CS 0.1mCi)and188Re-S + CS(0.2mCi)group.The mice tumor was injected with corresponding reagent respectively, and the inhibitoy rate of tumor was observed after administrated.Results The growth of tumors in 188Re + CS group and 188Re-S + CS group was slowed.the tumor inhibitory rate reached the highest level after 6 days therapy, which respectively was 67.35％ and 67.81％.Conclusions Internal irradiation of interventional radionuclide 188 Re in thermosensitive ehitosan had the effect of inhibitory mice liver cancer.%目的 研究温敏型壳聚糖(chitonsan CS)介入核素188Re内照射对小鼠移植性肝RW(H22)的抑制作用.方法 建立小鼠肝癌(H22)模型后随机分成7组,即模型对照组、.88Re(0.1mCi)组、188Re-S (0.1mCi)组、188Re +CS (0.1 mci)组、188Re + CS (0.2mCi)组、188Re+硫胶体+壳聚糖(188Re-S + CS 0.1 mCi)组和188Re-S + CS (0.2mCi )组.各组动物瘤内分别注射相应试药,测定肿瘤抑制率.结果 188Re + CS组和188Re-S + CS组肿瘤生长速度减慢,肿瘤生长延迟,肿瘤抑制率在治疗后6d最高,抑制率分别为67.35%和67.81%.结论 温敏型壳聚糖介入核素188Re内照射对小鼠肝癌(H22)具有一定的抑制作用.