Objective To investigate the resistance of clinical isolates from central - south region of China to antimicrobial agents commonly used from 2010 to 2011. Methods Disk diffusion susceptibility test was used to determine the antimicrobial susceptibility. Data was analyzed by Whonet 5. 6 software. Results Of 78569 clinical isolates,67. 3% was Gram - negative bacilli and 32. 7% was Gram - positive cocci. 26. 6% of Gram - negative bacilli was E. Coli and 18. 4% of Gram - negative bacilli was Pseudomonas aeruginosa and 15% of Gram - negative bacilli was K. Pneumonia. 36% of bacteria came from sputum and 15. 7% of bacteria came from urine and 9. 4% came from blood. None of Staphylococcus au-reus was resistant to vancomycin, teicoplanin and linezolid. 1.7% of coag-ulase - negative Staphyloccus were resitant to teicoplanin. None of coagu-lase - negative Staphyloccus were resitant to vancomycin and linezolid. 0.6% of E.faecallis and 1.1% of E.faecium were resistant to vancomycin. 1.5% of E.faecallis and 1.3% of E.faecium were resistant to teicoplanin. Noneof them was resistant to linezolid. 3. 3% of E. Coli ,6. 5% of K. Pneumonia and 5. 6% of E. Cloacae were resistant to imipenem and 4. 1% of E. Coli,6. 5% of K. Pneumonia and 4. 7% of E. Cloacae were resistant to meropenem. Enter-obacteriaceae resistant to carbopenems were widespred. Conclusion Enterobacteriaceae resistant to carbapenem, VRE and coagulase - negative Staphyloccus resistant to teicoplanin were produced . The control of the resistance of clinical I-solates was austere.%目的 总结中南地区2010年度临床分离菌株对常用抗菌药物的耐药情况.方法 用纸片扩散法进行药物敏感性试验,经Whonet 5.6软件进行数据分析.结果 78569株细菌中,革兰阴性菌52875株,占67.3％；革兰阳性菌25694株,占32.7％.检出的革兰阳性菌主要有葡萄球菌属、肠球菌属和链球菌属,分别占21.5％,10.7％和3.7％.检出的革兰阴性菌主要有大肠埃希菌、铜绿假单胞菌和肺炎克雷伯菌,分别占26.6％,18.4％和15.0％.分离的菌株主要来自痰(36.0％)、尿(15.7％)和血液(9.4％).金葡菌中未发现对万古霉素、替考拉宁和利奈唑胺的不敏感菌株.凝固酶阴性葡萄球菌对替考拉宁的耐药率为1.7％；未发现对万古霉素和利奈唑胺的不敏感菌株.粪肠球菌和屎肠球菌对万古霉素的耐药率分别为0.6％和1.1％；对替考拉宁的耐药率分别为1.5％和1.3％；未发现对利奈唑胺的不敏感菌株.肠杆菌科细菌中,普遍出现了对碳青霉烯类抗生素的耐药菌株,大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌、产气肠杆菌、粘质沙雷菌、弗劳地枸橼酸杆菌和奇异变形杆菌对亚胺培南和美罗培南的耐药率分别为3.3％,4.1％；6.5％,6.5％；5.6％,4.7％；5.8％,4.7％；7.5％,5.5％；4.6％,5.6％和12.8％,4.8％.结论 肠杆菌科细菌中普遍出现了对碳青霉烯类抗生素的耐药菌株,革兰阳性菌种出现了对替考拉宁耐药的凝固酶阴性葡萄球菌和对万古霉素耐药的肠球菌.
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