Objective: To evaluate factors that affect recurrence ofⅠb-Ⅱa cervical cancer after surgery or radiation therapy, and to provide evidence for prevention and personalized treatment of cervical cancer recurrence. Methods: We retrospectively analyzed clini-cal and pathological data of 193 patients with stageⅠb-Ⅱa cervical cancer who were diagnosed and treated in Affiliated Cancer Hos-pital of Xinjiang Medical University from January 2010 to April 2015. The patients were assigned into the following two groups: postop-erative radiotherapy recurrence group (36 cases) and non-recurrence group (157 cases). Factors related to recurrence after postopera-tive radiotherapy were analyzed. Results: The incidence rates of squamous cell carcinoma, adenocarcinoma, and other cervical cancer types were 90.2% (174/193), 5.7% (11/193), and 4.1% (8/193), respectively. The recurrence rates of squamous cell carcinoma, adeno-carcinoma, and other cervical cancer types were 16.7% (29/174), 45.5% (5/11), and 25.0% (2/8), respectively. The difference was statis-tically significant (χ2=12.463, P<0.05). The proportion of patients with age≤40 years, adenocarcinoma, vaginal margin, vascular inva-sion, lymph node metastasis, and parametrial invasion was higher in the relapse group than in the non-relapse group; the difference was statistically significant between the two groups (P<0.05). The odds ratio (OR) values for positive vaginal margin, positive vascular invasion, and positive parametrial invasion were above 1 (P<0.05). Therefore, these three factors were independent risk factors for cer-vical cancer recurrence after radiotherapy. Conclusions: Among stage Ib-IIa cervical cancer cases, squamous cell carcinoma had the highest recurrent incidence. However, the rate of recurrence after surgery or radiation therapy was the highest for adenocarcinoma. Postoperative pathology suggests that patients with positive vaginal margins, positive vascular infiltration, and positive parametrial in-vasion have a high risk of recurrence after radiotherapy and should be followed-up carefully.%目的:探讨影响Ⅰb～Ⅱa期宫颈癌术后放疗后复发的相关因素,为宫颈癌术后放疗后复发的预防及个性化综合治疗提供依据.方法:回顾性分析2010年1月至2015年4月193例于新疆医科大学附属肿瘤医院诊断并接受规范治疗的Ⅰb～Ⅱa期宫颈癌患者的临床病理资料,分为术后放疗后复发组36例和未复发组157例,并对患者术后放疗后复发的相关因素进行分析.结果:193例宫颈癌患者中鳞癌、腺癌、其他病理类型的发病率分别为90.2%(174/193)、5.7%(11/193)、4.1%(8/193).鳞癌、腺癌及其他病理类型宫颈癌的复发率分别为16.7%(29/174)、45.5%(5/11)、25.0%(2/8),比较不同病理类型宫颈癌的复发率,差异具有统计学意义(χ2=12.463,P<0.05).复发组年龄≤40岁、腺癌、阴道切缘阳性、有脉管浸润、淋巴结转移、有宫旁受侵的构成比高于未复发组,两组进行比较差异具有统计学意义(P<0.05).阴道切缘阳性、有脉管浸润、有宫旁受侵是宫颈癌术后放疗后复发的独立危险因素.结论:Ⅰb～Ⅱa期宫颈癌中鳞癌的发病率最高,但腺癌术后放疗后的复发率最高.术后病理提示阴道切缘阳性、有脉管浸润、有宫旁受侵的患者术后放疗后复发风险高,应严密随访.
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