羟基喜树碱、氨甲喋呤、5-氟脲嘧啶和醛氢叶酸联合化疗治疗晚期复发性乳腺癌

摘要

Objective:The therapeutic efficacy and side effects of combined chemotherapy of HCPT,MTX,LV and 5-Fu for metastatic or recurrent breast cancer were evaluated in our study.Methods:A total of 43 cases of advanced metastatic or recurrent breast cancer were treated with chemotherapy regimen consisting of HCPT 10mg/m2 iv gtt for dl～5,MTX 100mg iv dl,Leucovorin 150mg/m2 iv gtt for d2～4,5-Fu 500mg/m2 iv gtt for dl～5.The cycle was repeated every 4 weeks,and 2 cycles were given as one course.Results:The overall CR+PR was 47%.One year survival rate was 54% and the median survival interval was 19 months.The main side effects were bone marrow suppression and gastrointestinal reaction.Conclusion:The combined chemotherapy regimen consisting of HCPT etc is beneficial for metastatic breast cancer.%目的：观察包含羟基喜树碱的联合化疗方案治疗晚期复发性乳腺癌的疗效及毒副作用。方法：43例乳腺癌患者均为术后或放疗后、并且已行系统化疗结束后复发或转移复治的病例。化疗方案为羟基喜树碱10mg／m2静滴，第1～5日；氨甲喋呤100mg静冲，第1日、醛氢叶酸150mg／m2第2～4日，静滴；5-氟脲嘧啶500mg／m2静滴，第1～5日；每28日为一周期，连用两个周期以上。结果：总有效率47％，1年生存率54％，中位生存期为19个月。主要毒副作用为轻度的血液和消化道反应。结论：含羟基喜树碱的HMLF方案是治疗晚期复发性乳腺癌有效且毒性较小的联合化疗方案。