多配体聚糖结合蛋白在乳腺癌及其他恶性肿瘤中作用的研究进展

摘要

Syndecan binding protein (SDCBP) has been identified as a molecule linking syndecan-mediated signaling to the cyto-skeleton;SDCBP has also contributed to the development of many malignancies, including breast cancer. Breast cancer is a heteroge-neous disease encompassing multiple subgroups with different molecular signatures, clinical characteristics, and responses to therapies. This article reviews the pathways of SDCBP interaction and its functions in the tumor progression of breast cancer and other malignan-cies to provide novel ideas of targeted therapies for breast cancers, particularly triple-negative and endocrine therapy-resistant breast cancers and other malignancies, that lack effective individualized treatments.%多配体聚糖结合蛋白(SDCBP)是一种将多配体聚糖介导的信号与细胞骨架联系起来的分子,与多种恶性肿瘤的进展密切相关.乳腺癌是一种包含多种亚型的异质性疾病,具有不同的分子表型、临床特征以及对治疗的不同反应.为对那些缺乏有效个体化治疗手段的乳腺癌特别是三阴性乳腺癌和内分泌治疗耐药的乳腺癌,及其他恶性肿瘤的靶向性治疗提供新的思路,本文将就SDCBP在乳腺癌及其他恶性肿瘤中参与的信号转导途径和发挥的作用进行综述.