小脑肽1对浦肯野细胞突触形成作用的最新研究进展

摘要

Cerebellin 1 is a glycoprotein in the cerebellum, which is produced and secreted from granule cells and works as a strong synapse organizer between Purkinje cells and parallel ifbers, the axons of the granule cells. The molecular mechanisms by which Cbln1 induces synapse formation were described and the related literature was reviewed.%小脑肽1是一种小脑中的特异性糖蛋白，由颗粒细胞生成并分泌，在颗粒细胞的平行纤维和浦肯野细胞之间的兴奋性突触形成过程中发挥重要作用。文中将详细描述小脑肽1诱导新生突触形成的分子机制。复习相关方面的文献，就小脑肽1对于浦肯野细胞上突触的形成以及兴奋与抑制传入的调节作用的研究现状作详细介绍。