鼻胆管引流对内镜逆行胰胆管造影术后高淀粉酶血症及胰腺炎的预防结果

摘要

目的：探讨鼻胆管引流用于预防内镜逆行胰胆管造影术（ERCP）后高淀粉酶血症和胰腺炎的临床效果。方法：将120例拟行 ERCP 的患者随机分为对照组和试验组，每组各60例。对照组患者在 ERCP 后，未给予鼻胆管引流；试验组患者在ERCP 后，给予鼻胆管引流。分别在术后3、12、24 h 测定2组患者血清淀粉酶水平，比较2组患者高淀粉酶血症及胰腺炎的发生率。结果：试验组和对照组患者的性别、年龄等差异均无统计学意义（P ＞0．05）。试验组高淀粉酶血症发生率为10％，显著低于对照组（26．7％），P ＜0．01；试验组胰腺炎发生率为3．33％，显著低于对照组（11．67％），P ＜0．05。试验组术后3、12、24 h血清淀粉酶水平明显低于对照组（P ＜0．05）。结论：ERCP 术后行鼻胆管引流可有效预防高淀粉酶血症及胰腺炎的发生，值得推广。%Objective:To observe the clinical effect of endoscopic nasobiliary drainage on the prevention of hyperamylasemia and pancreatitis after endoscopic retrograde cholangiopancreatography(ERCP).Methods:A total of 120 patients who were go-ing to undergo ERCP were selected as the research object and randomly divided into the control group(n=60)and the experi-mental group(n=60).After ERCP,patients in the control group did not receive endoscopic nasobiliary drainage,and patients in the experimental group received endoscopic nasobiliary drainage.At 3,12,24 h after ERCP,the level of serum amylase was detected,and the incidence rates of hyperamylasemia and pancreatitis in the two groups were compared.Results:There was no significant difference in the gender,age,etc.between the experimental group and the control group(P >0.05).The incidence rate of hyperamylasemia in the experimental group was 10%,significantly lower than that in the control group (26.7%),P <0.01.The incidence rate of pancreatitis in the experimental group was 3.33%,significantly lower than that in the control group (11.67%),P <0.05.The levels of serum amylase in the experimental group were significantly lower than that in the control group at 3,12,24 h after ERCP(P <0.05).Conclusions:Endoscopic nasobiliary drainage given after ERCP can effec-tively reduce the incidence rates of hyperamylasemia and pancreatitis.