消化性溃疡合并2型糖尿病患者体内内皮祖细胞的变化

摘要

Objective:To explore the changes of the number and functions of endothelial progenitor cell (EPC)in the peripheral blood of patients with peptic ulcer combined with type 2 diabetes.Methods:Thirty-two patients with peptic ulcer combined with type 2 diabetes (Group A),32 patients with peptic ulcer not combined with type 2 diabetes(Group B),and 32 healthy volun-teers in the same term(Group C)were selected.The number and adhension,proliferation and migration functions of EPC in each group were detected.Results:The numbers of EPC in Group A and Group B were significantly lower than that in Group C (P <0.05),and the number of EPC in group A was lower than that in Group B.The adhesion,proliferation and migration functions of EPC in Group A and B were lower than those in Group C(P <0.05),and those features in Group A were lower than those in group B.Conclusions:In patients with peptic ulcer combined with type 2 diabetes mellitus,the number of EPC decreased while the function of EPC was impaired.EPC may be involved in the occurance and development of peptic ulcer com-bined with type 2 diabetes.%目的：探讨消化性溃疡合并2型糖尿病患者外周血中内皮祖细胞（endothelial progenitor cell，EPC）数量、功能的变化。方法：选择消化性溃疡合并2型糖尿病的患者32例（A 组）、消化性溃疡不合并2型糖尿病的患者32例（B 组）及同期健康志愿者32例（C 组）。检测各组 EPC 的数量及黏附、增殖、迁移能力。结果：A 组和 B 组的 EPC 数量明显低于 C 组（P ＜0．05），且 A 组 EPC 数量低于 B 组（P ＜0．05）；A 组和 B 组 EPC 的黏附、增殖及迁移能力均明显低于 C 组（P ＜0．05），且 A 组 EPC 的黏附、增殖及迁移能力低于 B 组。结论：2型糖尿病合并消化性溃疡患者的 EPC 数量减少、功能受损；EPC 可能参与了消化性溃疡合并2型糖尿病的发生、发展。