肝内胆管细胞癌中E3泛素化连接酶UHRF2的表达及临床意义

摘要

目的:探讨E3泛素化连接酶UHRF2在肝内胆管细胞癌(intrahepatic cholangiocarcinoma,ICC)中的表达及其临床意义.方法:采用免疫组织化学法检测UHRF2在138例ICC患者癌组织中的表达,分析其与ICC患者预后及临床病理特征的关系.结果:UHRF2在ICC组织中表达上调.UHRF2在不同甲胎蛋白(AFP)水平(P=0.010)、肿瘤分化程度(p=0.026)、淋巴结转移情况(P=0.001)、TNM分期(P=0.019)患者中差异均有统计学意义.UHRF2高表达组患者5年生存率低于低表达组,5年累计复发率高于低表达组(P＜0.001).多因素分析提示UHRF2是ICC的预后指标(P＜0.05).结论:UHRF2表达与ICC恶性程度正相关,可作为ICC患者预后和术后复发的预测指标.%Objective:To explore the expression and clinical significance of ubiquitin-like with PHID and ring finger domains 2 (UHRF2) in intrahepatic cholangiocarcinoma (ICC).Methods:The expression of UHRF2 in 138 ICC was determined by immunohistochemistry,and the relationships between UHRF2 expression with prognosis and clinicopathological features of ICC were analyzed:Results:UHRF2 was highly expressed in ICC compared with paratumorous tissues.Level of UHRF2 was associated with high AFP level (P=0.010),poor tunor differentiation (P=0.026),lymph node metastasis (P=0.001),and advanced TNM stage (P=0.019).Hevated UHRF2 expression was suggested to be associated with poor prognosis and high recurrence rate in ICC patients (P＜ 0.001),and multivariable analysis indicated that UHRF2 was of theprognostic indicators of ICC (P＜0.05).Conclusions:High level of UHRF2 is related to the malignant phenotype of ICC,and can be a prognostic and recurrent indicator of postoperative patients.