非乙醇性脂肪肝病患者身体成分及其危险因素分析

摘要

目的：探讨非乙醇性脂肪肝病（NAFLD）患者与正常人群身体成分的差异及 NAFLD 的危险因素。方法选择40～69岁 NAFLD 患者172例，179名体检健康者（对照组）；分别测量两组的身体成分和血生化指标。结果NAFLD 组细胞内液百分比、细胞外液百分比（ECW％）、蛋白质百分比、无机盐百分比、细胞外液与细胞内液比及高密度脂蛋白胆固醇均低于对照组（P ＜0．05），而体脂肪百分比、体质量指数、腰围、臀围、腰臀比（WHR）及内脏脂肪面积、空腹血糖、总胆固醇、三酰甘油（TG）、极低密度脂蛋白胆固醇、低密度脂蛋白胆固醇均高于对照组，差异有统计学意义（P ＜0．05）。Logistic 回归分析显示，WHR、ECW％、TG 与NAFLD 具有相关性。结论NAFLD 患者的人体成分与健康人相比存在差异，代谢紊乱明显；NAFLD 的发生可能与腹型肥胖、细胞外液百分比减少及高三酰甘油血症存在一定的关系。%Objective To explore the risk factors for NAFLD between the non-alcoholic fatty liver disease (NAFLD)patients and normal population.Method One hundred and seventy two cases with NAFLD and 1 79 healthy cases (control group)aged between 40 to 69 were collected;The body composition and serum biochemical were measured in both groups.Results The percentage of intracellular fluid (ICW%),percentage of extracellular fluid (ECW%),protein percentage (Protein%),inorganic salts percentage (Mineral%),extracellular fluid and in-tracellular fluid ratio (ECW/ICW),high-density lipoprotein cholesterol (HDL-C)of NAFLD were lower than those of the control group (P <0.05)(body fat%),and the body fat percentage,body mass index (BMI),waist circumfer-ence (WC)and hip circumference (HC),waist hip ratio (WHR)and visceral fat area (VFA),fasting plasma glu-cose (FPG),total cholesterol (TC),triglyceride (TG),very low density lipoprotein cholesterol (VLDL-C),low-den-sity lipoprotein cholesterol (LDL-C)were those of higher than the control group (P <0.05).The logistic regression analysis showed that WHR,TG ECW% were related with NAFLD.Conclusions The body composition of NAFLD is different with healthy people.The NAFLD may be related to abdominal type obesity,extracellular fluid percentage re-duction and hypertriglyceridemia.