重型颅脑外伤患者亚低温治疗后血管内皮生长因子表达水平研究

摘要

目的 探讨亚低温疗法对重型颅脑损伤(sTBI)患者血管内皮生长因子(VEGF)表达的影响.方法纳入148例急性重型颅脑损伤患者(格拉斯哥评分为3~8分),65例行亚低温治疗,83例行常规治疗.术后1周监测血清VEGF表达水平,术后6个月采用评价格拉斯哥预后评分(GOS)评价治疗效果.结果 亚低温治疗组患者术后1周血清VEGF表达水平明显低于常规治疗组在同期的血清VEGF表达水平(P<0.01).亚低温治疗组患者伤后6个月的GOS评级明显好于常规治疗组(P=0.007),良好或轻残比例增加,重残和植物生存比例减少.结论 对于重型颅脑外伤患者,亚低温治疗可能通过抑制血清VEGF表达,提高患者的术后6个月治疗效果.%Objective To study the effect of hypothermia therapy on the expression of vascular endothelial growth factor (VEGF) in patients with severe traumatic brain injury (sTBI).Methods This study included 116 cases of patients with acute severe craniocerebral injury treated.The Glasgow scores of the patients were scaled between 3 to 8 points.Among them,a total of 52 cases underwent postoperative hypothermia treatment,and a total of 64 cases underwent routine treatment.The blood VEGF expression was tested at a week after surgery,and the GOS was examined at six months after surgery.Results The blood VEGF expression of patients with hypothermia treatment was significantly lower than that of patients with routine treatment at one week after surgery (P<0.01).The GOS of patients with hypothermia treatment was significantly higher than that of patients with routine treatment at the sixth months after surgery (P=0.007).Conclusion The hypothermia treatment could inhibit VEGF expression and consequently lead to a good prognosis of patients with sTBI.