类风湿性关节炎滑膜组织中PTTG1和MMP—2的表达及意义

摘要

Purpose To detect the expression and distribution of PTTG1 and MMP-2 in synovial tissue of rheumatoid arthritis and to discuss their roles in the mechanism of rheumatoid arthritis. Methods SP immunohistochemical method was used to detect the expression of PTTG1 and MMP-2 in synovium of 68 rheumatoid arthritis cases and 14 osteoarthritis cases. Results The positive rates of PT-TG1 were 64. 7% in RA groups and 21. 4% in OA groups. The positive rates of MMP-2 were 73. 5% in RA groups and 28. 6% in OA groups. The expression of PTTG1 in RA group was significantly higher than that of OA group. The expression of MMP-2 in RA group was significantly higher than that of OA group. And there was correlation between PTTG1 and MMP-2. Conclusion The expression of both PTTG1 and MMP-2 increases in synovium of RA and there is significant correlation between them, which thereby suggests that they may have certain association in the pathogenesis of rheumatoid arthritis.%目的 检测类风湿性关节炎(rheumatoid arthritis,RA)患者滑膜被覆细胞及滑膜下组织中垂体肿瘤转化基因1(pituitary tumor transforming gene 1,PTTG1)及MMP-2的表达及分布状况,探讨其在RA发病中的作用.方法 采用免疫组化SP法检测68例RA患者,14例骨性关节炎(osteoarthritis,OA)患者滑膜被覆细胞及滑膜下组织中PTTG1及MMP-2的表达状况.结果 PTTG1在RA组、OA组阳性率分别为64.7%和21.4%;MMP-2在RA组、OA组阳性率分别为73.5%和28.6%,差异具有统计学意义(P<0.05),且PTTG1和MMP-2之间表达具有相关性(rs=0.776,P<0.05).结论 PTTG1和MMP-2在RA组滑膜组织的表达均明显升高,且二者之间的表达具有相关性,从而证实其在RA的发病机制中可能具有一定的作用.