间苯二酚保护的抗菌Pd纳米粒子催化C-C偶联反应活性

摘要

Novel tetra‐methoxy resorcinarene tetra‐hydrazide (TMRTH) has been synthesized and used as a reducing agent and a capping agent for the synthesis of water‐dispersible stable palladium nano‐particles (PdNPs). The TMRTH‐PdNPs were characterized by UV‐Vis spectroscopy, transmission electron microscopy, energy‐dispersive X‐ray spectroscopy, and powder X‐ray diffraction. The syn‐thesized nanoparticles are polydispersible with a size of 5 ± 2 nm and were found to be recyclable over five cycles maintaining a catalytic activity in the Suzuki‐Miyuara cross‐coupling reaction. The nanocatalyst was superior in catalytic performance to conventional palladium catalysts with respect to reaction time, catalyst loading and recyclability. TMRTH‐PdNPs show promise for their use in biological applications as they exhibit good antibacterial activity against gram‐positive bacteria.%合成了新型四甲氧基间苯二酚-四酰肼(TMRTH),并作为还原剂和封端剂用于合成水分散性稳定的Pd纳米粒子(PdNPs)。采用紫外-可见光谱、透射电镜、能量散射谱和粉末X射线衍射对所得TMRTH-PdNPs样品进行了表征。结果表明,所制纳米粒子具有多分散性,粒径为5±2 nm,并在Suzuki-Miyuara交叉偶联反应中可重复使用5次,具有较高的催化效率。该纳米催化剂在反应时间、催化剂用量和可重复使用性能等方面优于常规Pd催化剂。另外, TMRTH-PdNPs样品对革兰(氏)阳性菌具有较好的抗菌活性,因而有望用于一些生物领域。