高血压患者主动脉脉搏波传导速度影响因素探究

摘要

Objective : To analyze influencing factors of aortic pulse wave velocity (APWV) in patients with essential hypertension (EH).Methods : The 336 EH patients from our hospital were divided into elevated APWV group (n＝281) and normal APWV group (n＝55)- Clinical data were compared between two groups ,and multi-factor Logis-tic regression was used to analyze influencing factors of APWV in EH patients .Results : Compared with normal AP-WV group ,there were significant rise in age [ (56-71 ± 11-45) years vs-(62-98 ± 12-36) years] ,percentages of di-abetes mellitus (5-45% vs- 19-22%) ,obesity (18-18% vs- 23-84%) ,smoking (16-36% vs- 30-60%) , EH stage 3 (12-73% vs- 32-03%) ,body mass index [BMI , (22-53 ± 2-07) kg／m2 vs-(23-28 ± 2-04) kg／m2 ] ,systolic blood pressure SBP [ (139-64 ± 12-85) mmHg vs.(147-39 ± 13-30 ) mmHg] ,diastolic blood pressure DBP [ (93-18 ± 8-73) mmHg vs .(96-43 ± 9-14 ) mmHg] , TC [ (5-18 ± 0-91 ) mmol／L vs-(5-65 ± 1-03 ) mmol／L ] , LDL-C [ (3-00 ± 0-68 ) mmol／L vs-(3-24 ± 0-72 ) mmol／L ] ,serum creatinine SCr [ (110-71 ± 52-39 ) μmol／L vs-(138-52 ± 63-65) μmol／L] ,serum uric acid SUA [ (318-73 ± 102-62) μmol／L vs-(354-28 ± 108-35) μmol／L] , and significant reduction in level of HDL-C [ (1-19 ± 0-32) mmol／Lvs-(1-09 ± 0-30) mmol／L] in elevated AP-WV group , P＜0-05 or ＜0-01- Multi-factor Logistic regression analysis indicated that age ,diabetes mellitus ,SBP , TC ,SCr and EH stage were independent risk factors for APWV (OR＝2-826 －3-732 , P＜0-05 all).Conclusion :Age ,diabetes mellitus ,SBP ,TC ,SCr and EH stage are risk factors for APWV in EH patients- Therefore ,corre- sponding preventive and therapeutic measures should be taken to improve prognosis .%目的:分析原发性高血压(EH )患者主动脉脉搏波传导速度(APWV )的影响因素.方法:我院336例EH患者被分为APWV升高组(281例)和APWV正常组(55例) ,对比两组临床资料,采用Logistic多元回归分析EH患者 APWV 的影响因素.结果:与 APWV 正常组比较, APWV 升高组年龄[ (56-71 ± 11-45 )岁比(62-98 ± 12-36)岁] ,糖尿病(5-45% 比19-22%) 、肥胖(18-18% 比23-84%) 、吸烟史(16-36% 比30-60%) 、高血压3级(12-73% 比32-03%)比例,人体质量指数(BMI) [ (22-53 ± 2-07 ) kg／m2 比(23-28 ± 2-04) kg／m2 ] , SBP [ (139-64 ± 12-85) mmHg比(147-39 ± 13-30) mmHg] 、 DBP [ (93-18 ± 8-73) mmHg比(96-43 ± 9-14) mmHg] , TC [ (5-18 ± 0-91) mmol／L比(5-65 ± 1-03 ) mmol／L ] 、 LDL-C [ (3-00 ± 0-68 ) mmol／L比(3-24 ± 0-72 ) mmol／L ] 、 SCr [ (110-71 ± 52-39 ) μmol／L 比(138-52 ± 63-65 ) μmol／L ] 、 SUA [ (318-73 ± 102-62) μmol／L比(354-28 ± 108-35 ) μmol／L ]水平显著升高, HDL-C (1-19 ± 0-32 ) mmol／L 比(1-09 ± 0-30) mmol／L显著降低(P＜0-05或＜0-01) .多因素 Logistic回归分析显示,年龄、糖尿病、 SBP 、 TC 、 SCr 、高血压等级是影响APWV的独立危险因素(OR＝2-826～3-732 , P均＜0-05) .结论:年龄、糖尿病、 SBP 、 TC 、SCr 、高血压等级是影响原发性高血压患者APWV的危险因素,因此,应采取相应的防治措施改善预后.