目的:探讨不同他汀类药物在颈动脉粥样硬化患者中的作用.方法:102例颈动脉粥样硬化患者被随机均分为阿托伐他汀组(给予阿托伐他汀钙片20mg/d),普伐他汀组(给予普伐他汀钠片20mg/d),分别比较不同他汀片治疗后脑梗塞和肝功能异常的发生率.结果:治疗两年内,阿托伐他汀组脑梗塞发生率明显低于普伐他汀组(3.9%比15.7%,P<0.05),肝功能异常发生率明显高于普伐他汀组(13.7%比2.0%,P<0.05).结论:阿托伐他汀较普伐他汀具有较强的调控血脂,稳定动脉粥样斑块的作用,脑梗塞发生率较低,但是在长期治疗过程中,肝功能异常发生率要高于普伐他汀治疗.%Objective: To investigate effects of different statins on patients with carotid atherosclerosis. Methods: A total of 102 cases with carotid atherosclerosis were randomly and equally divided into two groups-, atorvastatin group (received atorvastatin calcium 20mg/d) and provastatin group (received provastatin sodium 20mg/d). Incidence rates of cerebral infarction and liver dysfunction in the two groups were observed after treatment. Results; During two—year treatment with different statins, incidence rate of cerebral infarction in atorvastatin group was significantly lower than that of provastatin group (3. 9％ vs. 15. 7％, P＜0. 05) and incidence rate of liver dysfunction was significantly higher than that of provastatin group (13. 7％ vs. 2. 0％, P＜0. 05). Conclusion: Compared with provastatin, atorvastatin is better in regulation of blood lipids and stabilization of atherosclerotic plaques, and incidence rate of cerebral infarction is lower, but incidence rate of liver dysfunction is high than that of provastatin treatment.
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