稳心颗粒对心肌梗死后抑郁大鼠心脏电生理的影响

摘要

目的:运用稳心颗粒干预心肌梗死后合并抑郁大鼠,探讨其对心梗后抑郁大鼠心脏电生理的影响.方法:选择SD大鼠50只,均分为正常组,心梗组,抑郁组,心梗后抑郁组(模型组)和稳心颗粒干预组(以2g/d的稳心颗粒给模型组大鼠灌胃28d).先后急性结扎左冠脉和予以慢性不可控的温和应激,制作心肌梗死后抑郁模型大鼠,予稳心颗粒干预,评价其对模型大鼠在体单向动作电位(MAP90)、左室有效不应期(ERP)和室颤阈值(VFT)等电生理学指标的影响.结果:(1)与正常组相比,模型组行为学评分有显著下降(P＜0.05),经过4周稳心颗粒治疗后,其行为学评分显著上升(P＜0.01)；(2)与正常组相比,模型组MAPD90和ERP明显延长,VFT明显降低(P＜0.05)；稳心颗粒干预后,与模型组比较,稳心颗粒组MAPD90[(89.33±7.12)ms比(72.29±8.37)ms]、ERP[(84.00±6.57) ms比(68.00±7.43)ms]明显缩短,VFT[(7±3.11)V比(29±5.60) V]明显升高(P＜0.05).结论:稳心颗粒能改善心肌梗死后抑郁大鼠心脏电重构,包括缩短单向动作电位和左室有效不应期,增加室颤阈值.%Objective:To investigate influence of Wenxin particle on cardiac electrophysiology in rats complicated with depression after myocardial infarction (MI).Methods:A total of 50 SD rats were randomly and equally divided into normal group,MI group,depression group,MI complicated depression group (modeI group) and Wenxin particle group (Wenxin particle were given to model rats by gavage,2 g/d,28d).Model (MI complicated with depresion) rats were made by acute ligation of left coronary artery and supply chronic unpredictable mild stress in order.The influences of wencin particle on cardiac electrophysiological indexes,such as monophasic action potential (MAP90),left ventricular effective refractory period (ERP) and ventricular fibrillation threshold (VFT) were evaluated in wencin particle group.Results:(1) Compared with normal group,there were significant decrease in behavior scores (P＜0.05) in model group,after four-week treatment with Wenxin particle,their behavior scores significantly increased; (2) Compared with normal group,there were significant increase in MAPD90 and ERP,and significant decrease in VFT in model group (P＜0.05) ; compared with model group,there were significant decrease in MAPD90 [(89.33±7.12) ms vs.(72.29±8.37) ms] and ERP [(84.00±6.57) ms vs.(68.00±7.43) ms],and significant increase in VFT [(7±3.11) V vs.(29±5.60) V] in Wenxin particle group,P＜0.05.Conclusion:Wenxin particle can improve cardiac electrical remodeling in rats complicated with depression after myocardial infarction,including decrease monophasic action potential duration and effective refractory period,and raise ventricular fibrillation threshold.