焦虑或抑郁情绪对原发性高血压患者血栓前状态的影响

摘要

Objective:To observe influence of anxiety or depression on prethrombotic state in patients with essential hypertension (EH).Methods:A total of 112 EH patients were equally divided into EH+A/D group and pure EH group.Levels of prethrombotic state indicators,including serum CD62P,von Willebrand factor (vWF),tissue type plasminogen activator (t-PA),plasminogen activator inhibitor (PAD-1 and endothelin (ET)-1 were measured in two groups.Results:Compared with pure EH group,there were significant increase in levels of CD62P [(4.52±2.01) ％ vs.(8.38±1.96) ％],vWF [(155.28±23.11) ％ vs.(185.23±22.21) ％],PAI-1 [(54.35±13.21) ng/Lvs.(79.88±14.53) ng/L] andET-1 [(121.56±33.32) ng/Lvs.(152.78±30.23) ng/L],P＜0.05all; and significant decrease in t-PA level [(19.37± 11.46) ng/L vs.(9.56±8.32) ng/L,P＜0.05] in EH+A/D group.Conclusion:Anxiety or depression can aggravate prethrombotic state of patients with essential hypertension through activation of platelets,influencing vascular endothelial function and fibrinolytic system imbalance.%目的:观察焦虑或抑郁情绪对原发性高血压患者血栓前状态的影响.方法:112高血压病患者被均分为高血压合并焦虑或抑郁组(EH+A/D组)和单纯高血压组(EH组),测定两组病人血清CD62P、血管假性血友病因子(vWF)、组织型纤溶酶原激活剂(t-PA)、组织型纤溶酶原激活剂抑制剂(PAI-1)、内皮素(ET)-1等血栓前状态指标水平.结果:与EH组比较,EH+A/D组CD62P[(4.52±2.01)％比(8.38±1.96)％]、vWF[(155.28±23.11)％比(185.23±22.21)％]、PAI-1[(54.35±13.21) ng/L比(79.88±14.53) ng/L]、ET-1[(121.56±33.32)ng/L比(152.78±30.23)ng/L]水平明显升高(P均＜0.05),而t-PA[(19.37±11.46) ng/L比(9.56±8.32) ng/L]水平明显降低(P＜0.05).结论:焦虑或抑郁情绪会通过激活血小板、影响血管内皮功能及纤溶系统的失衡,加重原发性高血压患者血栓前状态.