高血压患者升主动脉弹性与冠脉血流储备的相关性

摘要

目的:探讨高血压患者升主动脉弹性与冠状动脉血流储备(CFR)的相关性.方法:选择原发性高血压患者60例作为高血压组,并选择同期血压正常者50例作为正常对照组.采用组织多普勒超声检测,计算并比较两组患者的升主动脉扩张度(D值),僵硬度(β值)以及CFR.采用Pearson相关分析以分析β值,D值与CFR的相关性.结果:与正常对照组相比,高血压组患者D值[(3.59±0.30)10-6 cm2/d比(2.88±0.77)10-6 cm2/d]显著降低,β值[(3.54±1.52)比(5.46±1.98)]显著升高,P<0.05或<0.01;CFR[(3.23±1.16)比(2.02±0.63)]显著降低,P<0.01.Pearson相关分析显示高血压患者β值与CFR呈显著负相关(r=-0.413,P=0.005),D值与CFR呈显著正相关(r=0.384,P=0.003).结论:高血压患者升主动脉弹性下降与冠状动脉血流储备呈显著相关.%Objective:To explore the correlation between ascending aortic elasticity and coronary blood flow reserve (CFR)in patients with hypertension.Methods:A total of 60 patients with essential hypertension were regarded as hypertension group,another 50 normotensive subjects were enrolled as normal control group during the same period. Ascending aortic dilation (D),stiffness (β)and CFR were measured and calculated by tissue Doppler ultrasound,then compared between two groups.Pearson correlation analysis was used to analyze the correlation amongβ,D and CFR.Results:Compared with normal control group,there were significant reductions in D [(3.59±0.30)10-6 cm2/d vs.(2.88±0.77)10-6 cm2/d]and CFR [(3.23±1.16)vs.(2.02±0.63)],and significant rise inβ[(3.54 ±1.52)vs.(5.46±1.98)]in hypertension group,P<0.05 or<0.01. Pearson correlation analysis indicated thatβwas significant inversely correlated with CFR (r=-0.413,P=0.005),while D was significant positively correla- ted with CFR (r=0.384,P=0.003 ).Conclusion:Reduced ascending aortic elasticity is significantly correlated with coronary blood flow reserve.