CTRP-3水平和肥胖症的相关性研究

摘要

Objective:To study expression of complement C1q tumor necrosis factor related protein 3 (CTRP‐3 ) in obese patients and its significance .Methods :A total of 402 obese patients were enrolled as obesity group and 405 normal people undergoing physical examination were regarded as normal control group . The correlation among CTRP‐3 level and related indexes were analyzed ,and multi-factor regression analysis was used to study independent risk factors for obesity .Results:Compared with normal control group ,there were significant rise in body mass index (BMI) ,homeostasis model -insulin resistance index (HOMA-IR) ,levels of systolic blood pressure (SBP) ,diastolic blood pressure (DBP) ,total cholesterol (TC) ,low density lipoprotein cholesterol (LDL‐C) ,triglyceride (TG) ,fasting blood glucose (FBG) ,insulin ,glycosylated hemoglobin (HbA1c) and high sensitive C reactive protein (hsCRP) ,and significant reductions in levels of high density lipoprotein cholesterol (HDL‐C) ,adiponectin (APN) ,leptin and CTRP‐3 in obesity group , P<0.05 or <0.01 . Spearman correlation analysis indicated that after age and gender correction ,CTRP‐3 level was significant inversely correlated with BMI (r= -0.221) ,SBP (r= -0.031) ,DBP (r= -0.043) ,TC (r= -0.147) , LDL‐C (r= -0.051) ,TG (r= -0.743) ,FBG (r= -0.238) ,insulin (r= -0.053) ,HOMA -IR (r= -0.281) , HbA1c (r= -0.741) and hsCRP levels (r= -0.216) ,P<0.05 or <0.01 ,and significant positively correlated with lev‐els of HDL‐C (r=0.351) ,APN (r= 0.852) and leptin (r=0.641) ,P<0.05 all .Multi-factor regression analysis indi‐cated that after correcting other influencing factors ,compared with high tertile CTRP‐3 group ,there were significant rise in OR value in middle tertile CTRP‐3 group (OR=6.47 ,95% CI 3.58 -12.18) and low tertile CTRP‐3 group (OR=12.39 ,95% CI 3.58-29.15) , P<0.01 all .Conclusion:CTRP‐3 level is significantly correlated with obesity -related fac‐tors ,and it′s an independent risk factor for obesity .%目的：研究补体C1q肿瘤坏死因子相关蛋白3（CTRP‐3）在肥胖患者的表达及意义。方法：选择肥胖患者402例（肥胖组）和正常体检人员405例（正常对照组）。分析CTRP‐3水平与有关指标的相关性，并利用多因素回归分析研究肥胖的独立危险因素。结果：与正常对照组相比，肥胖组人体质量指数（BMI）、收缩压（SBP）、舒张压（DBP）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL‐C）、甘油三酯（TG）、空腹血糖（FBG）、胰岛素、稳态模型胰岛素抵抗指数（HOMA‐IR）、糖化血红蛋白（HbA1c）、高敏C反应蛋白（hsCRP）水平均显著升高，而高密度脂蛋白胆固醇（HDL‐C）、脂联素（APN）、瘦素和 CTRP‐3水平均显著降低， P＜0.05 或 ＜0.01。Spearman相关分析显示，校正年龄、性别后，CTRP‐3水平与BMI （r＝－0.221）、SBP （r＝－0.031）、DBP （r＝－0.043）、TC （r＝－0.147）、LDL‐C （r＝－0.051）、TG （r＝－0.743）、FBG （r＝－0.238）、胰岛素（r＝－0.053）、HOMA‐IR （r＝－0.281）、HbA1c （r＝－0.741）和hsCRP水平（r＝－0.216）呈显著负相关（P＜0.05或＜0.01），与 HDL‐C （r＝0.351）、APN （r＝0.852）和瘦素水平（r＝0.641）呈显著正相关， P均＜0.05。多因素回归分析显示，在调整了其他影响因素后，与高三分位数CTRP‐3组相比，中三分位数CTRP‐3组OR值6.47（95％ CI 3.58～12.18）和低三分位数CTRP‐3组OR值12.39（95％ CI 3.58～29.15）显著升高， P均＜0.01。结论：CTRP‐3水平与肥胖相关因素显著相关，低CTRP‐3水平是肥胖症的独立危险因素。