呋塞米并心脉隆注射液对心衰患者左室射血分数及r血乳酸的影响

摘要

Objective:To study influence of furosemide combined Xinmailong injection on left ventricular ejection fraction (LVEF)and blood lactate level in patients with chronic heart failure (CHF),and explore its therapeutic effect.Methods:Clinical data of 95 CHF patients treated in our hospital were retrospectively analyzed,including 48 cases using furosemide therapy (furosemide group),and 47 cases using furosemide combined Xinmailong injection (combined treatment group),both groups were treated for 15d.Therapeutic effect,LVEF, blood lactate and CA125 levels after treatment were compared between two groups.Results:Total effective rate of combined treat-ment group was significantly higher than that of furosemide group (87.23% vs.64.58%),P =0.01;compared with furosemide group after treatment,there were significant rise in LVEF [(49.6±3.6)% vs.(54.5±3.9)%],6min walking distance [(274.4±38.9)m vs.(359.5 ± 56.4)m]and maximum metabolic equivalent [(32.4 ±3.9 ) METs vs.(39.8±3.6)METs],and significant reductions in levels of blood lactate [(1.2±0.5)mmol/L vs.(0.7 ±0.3)mmol/L],CA125 [(55.6±6.9)IU/ml vs.(42.3±5.8)IU/ml],N-terminal pro brain natriuretic peptide [(2345.4±338.6)pg/ml vs.(1689.6±226.9)pg/ml]and serum uric acid [(402.4±43.9)mol/L vs.(359.8± 53.7)mol/L]in combined treatment group,P = 0.001 all.No severe adverse reactions occurred in two groups. Conclusion:Furosemide combined Xinmailong injection can significantly improve LVEF,reduce blood lactate level and improve heart function in CHF patients,and it′s safe and effective,which is worth extending in clinic.%目的:研究呋塞米与心脉隆注射液联合使用对慢性心力衰竭(CHF)患者左室射血分数(LVEF)及血乳酸值的影响,并探讨其治疗效果.方法:回顾性分析于我院接受治疗的95例CHF患者的临床资料,其中使用呋塞米治疗的患者48例(呋塞米组),心脉隆注射液与呋塞米联合治疗的患者47例(联合治疗组),两组均治疗15d.比较两组患者疗效及治疗后LVEF、乳酸水平、CA125等指标.结果:联合治疗组总有效率明显高于呋塞米组(87.23%比64.58%),P=0.01;治疗后,与呋塞米组比较,联合治疗组LVEF[(49.6±3.6)%比(54.5±3.9)%]、6min步行距离[(274.4±38.9)m比(359.5±56.4)m]、 最大代谢当量[METmax,(32.4±3.9)METs比(39.8±3.6)METs]明显增加,血乳酸水平[(1.2±0.5)mmol/L比(0.7±0.3)mmol/L]、CA125[(55.6±6.9)IU/ml比(42.3±5.8)IU/ml]、N末端脑钠肽前体[NT-proBNP,(2345.4±338.6)pg/ml比(1689.6±226.9)pg/ml]、血清尿酸[(402.4±43.9)mol/L比(359.8±53.7)mol/L]水平均显著降低(P均=0.001);两组患者均无严重不良反应发生.结论:呋塞米与心脉隆注射液联合治疗可明显提高慢性心力衰竭患者左室射血分数,降低其血乳酸水平,改善心功能,安全有效,值得在临床上推广和使用.