老年冠心病患者冠脉病变严重程度与血清UA及Hcy水平的相关性

摘要

Objective:To explore correlation among serum uric acid (UA), homocysteine (Hcy) levels and coronary disease severity in aged patients with coronary heart disease (CHD).Methods: A total of 98 aged CHD patients, who were treated in our department from Jan 2014 to Dec 2015, were selected.According to Gensini score, they were divided into low score group (≤30 scores, n=32), medium score group (30~60 scores, n=33) and high score group (≥60 scores, n=33).Serum concentrations of UA and Hcy, coronary stenosis degree calculated by Gensini score and coronary intimal atherosclerotic plaque proportion calculated by Sullivan score were measured and compared among three groups.Results: Compared with low Gensini score group, there were significant rise in serum concentrations of UA [(207.51±79.57) μmol/L vs.(324.12±81.36) μmol/L vs.(454.32±99.15) μmol/L] and Hcy [(10.32±6.84) μmol/L vs.(19.95±7.69) μmol/L vs.(28.92±7.85) μmol/L] in medium score group and high score group, and those of high score group were significantly higher than those of medium score group, P<0.05 or <0.01.Spearman rank correlation analysis indicated that serum UA concentration was significant positively correlated with serum Hcy concentration (r=0.557, P=0.042);Gensini score and Sullivan score were significantly positive correlated with serum concentrations of UA and Hcy in CHD patients (r=0.559~0.894, P<0.05 or <0.01).Conclusion: Coronary disease severity is significant positively correlated with serum concentrations of UA and Hcy in aged CHD patients.Their combined detection may have better effect, which is worth extending.%目的:探讨老年冠心病(CHD)患者冠脉病变严重程度与血清尿酸(UA)、同型半胱氨酸(Hcy)水平的相关性.方法:选择我院心内科于2014年1月至2015年12月收治的老年CHD患者98例.依据Gensini积分的不同,患者被分为低分组(≤30分,32例)、中分组(30~60分,33例)和高分组(≥60分,33例).检测比较三组的血清UA、Hcy浓度,用Gensini积分法、Sullivan积分法分别计算患者的冠脉狭窄程度、冠脉内膜粥样斑块比例.结果:与Gensini低分组比较,中分、高分组的血清UA [(207.51±79.57) μmol/L比(324.12±81.36) μmol/L比(454.32±99.15) μmol/L]和Hcy [(10.32±6.84) μmol/L比(19.95±7.69) μmol/L比(28.92±7.85) μmol/L]水平均显著升高,且高分组的显著高于中分组的,P<0.05或<0.01.Spearman等级相关分析显示,CHD患者血清UA浓度与血清Hcy浓度呈显著正相关(r=0.557, P=0.042);Gensini积分、Sullivan积分分别与血清UA、Hcy浓度呈显著正相关(r=0.559~0.894, P<0.05或<0.01).结论:老年冠心病患者冠脉病变的严重程度与血清UA、Hcy的浓度呈显著正相关,且联合检测效果可能更好,值得推广.