鼠疫耶尔森氏菌环二鸟苷酸代谢及生物被膜形成调控研究进展

摘要

鼠疫耶尔森氏菌(Yersinia pestis,以下简称“鼠疫菌”)是烈性传染病鼠疫的病原菌,以鼠蚤作为传播媒介.鼠疫菌在其传播媒介鼠蚤的前胃中形成生物被膜从而促进其在宿主间传播.鼠疫菌生物被膜的形成受第二信使分子环二鸟苷酸(c-di-GMP)的正向调控.鼠疫菌中c-di-GMP由二鸟苷酸环化酶(DGC) HmsT和HmsD合成,由磷酸二酯酶(PDE) HmsP降解.文申主要介绍影响鼠疫菌环二鸟苷酸代谢及生物被膜形成的调控因子,并对其作用机制进行讨论和总结.%Yersinia pestis,the cause of plague,is transmitted by flea bite.Y.pestis forms a biofilm in the proventriculus of its flea vector to enhance transmission.Biofilm formation in Y.pestis is positively regulated by the intracellular levels of the second messenger cyclic diguanylate (c-di-GMP).The c-di-GMP in Y.pestis is synthesized by two diguanylate cyclases (DGC),HmsT and HmsD,and degraded by phosphodiesterase (PDE),HmsP.Here we summarized the regulators that modulate c-di-GMP metabolism and biofilm formation in Y.pestis and discussed their regulatory mechanism.