丹参川芎嗪辅助治疗不稳定型心绞痛患者的疗效及其对实验室指标的影响

摘要

目的：观察丹参川芎嗪辅助治疗不稳定型心绞痛（ unstable angina pectoris ，UAP）的疗效及患者血脂、炎症细胞因子水平及心功能情况。方法以2013年5月～2015年5月在辽宁医学院附属第三医院心血管内科接受治疗的80例不稳定型心绞痛患者为研究对象，并按照随机数字表法分为对照组和观察组，每组各40例。其中对照组给予内科常规治疗，观察组在常规治疗的基础上辅以丹参川芎嗪注射液。以2周为1个疗程，比较2组患者的治疗效果及治疗前后血脂、炎症细胞因子和心功能相关指标水平的差异。结果治疗后，与对照组比较，观察组患者心绞痛症状控制（χ2＝8．658，P＝0．026）和心电图改善（χ2＝9．600，P＝0．020）的总有效率更优，甘油三酯（ triglyceride ，TG）、总胆固醇（ total cholesterol ，TC）、低密度脂蛋白胆固醇（ low－density lipoprotein cholesterol ，LDL－C）、TC／高密度脂蛋白胆固醇（high－density lipoprotein cholesterol，HDL－C）和LDL－C／HDL－C水平更低，HDL－C更高（P＜0．05），白介素－6（interleukin－6，IL－6）、超敏C反应蛋白（high－sensitivity C－reactive protein，hs－CRP）、肿瘤坏死因子－α（tumor necrosis factor－α，TNF－α）更低（ P＜0．05），每搏量（ stroke volume ， SV ）、左室收缩压（ left ventricular systolic pressure ， LVSP ）、左心室射血分数（ left ventricular ejection fraction，LVEF）水平更高，N末端－脑钠肽前体（N－terminal pro－brain natriurelic peptide，NT－proBNP）、心肌肌钙蛋白I（cardiac troponin I，cTnI）更低（P＜0．05）。结论丹参川芎嗪注射液可有效调节UAP患者的血脂、控制炎症因子水平，促进患者心功能的恢复，对改善患者心绞痛症状，促进疾病康复具有较好的促进作用。%Objective To observe the effect of Salvia TMP on the therapeutic, blood lipids, inflammatory cytokines and cardiac function in treatment of patients with unstable angina pectoris ( UAP) .Methods Eighty cases of patients with UAP treated in the hospital from May 2013 to May 2015 were selected and randomly divided into control group and observation group ,40 patients in each group.The control group received routine medical treatment,observation group supplemented Salvia TMP injection on the basis of conventional therapy.After two weeks for a course of treatment, the difference between the two groups of patients on therapeutic,blood lipid,inflammatory cytokines and cardiac function related indicators were compared. Results Compared with control group post-treatment, the symptom control and ECG effective rate of observation group were significantly higher (χ2 =8.658,P=0.026), the levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C),TC/high-density lipoprotein cholesterol(HDL-C) and LDL-C /HDL-C in observation group were lower(P<0.05),the level of HDL-C was higher(P<0.05), the levels of interleukin-6(IL-6), high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α(TNF-α) in observation group were significantly lower (P<0.05), the levels of stroke volume (SV), left ventricular systolic pressure (LVSP) and left ventricular ejection fraction (LVEF)were higher(P<0.05), the levels of N-terminal pro-brain natriurelic peptide (NT-proBNP) and cardiac troponin I (cTnI) were lower (P<0.05).Conclusion Salvia TMP injection could effectively regulate blood lipids in patients with UAP,control inflammation cytokines and promote the recovery of cardiac function , which has a good role in improving the symptoms of angina patients,promoting the recovery of disease.